SCHEMBL31489241

SCHEMBL31489241

Nc1nc2cc(I)cc(F)n2n1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.40
PIK3CD O00329 1/20 0.40
NUDT1 P36639 5/20 0.36
CALCA P06881 1/20 0.31
GPR119 Q8TDV5 1/20 0.31
KDM4E B2RXH2 2/20 0.31
ALDH1A1 P00352 1/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
PKM P14618 1/20 0.31
CHEK1 O14757 1/20 0.30
MET P08581 1/20 0.30
LTK P29376 1/20 0.30
CDK9 P50750 1/20 0.30
PRKX P51817 1/20 0.30
LRRK2 Q5S007 1/20 0.30
CLK4 Q9HAZ1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489196 0.74 JAK1 (0.39) PIK3CGPIK3CDNUDT1KDM4EALDH1A1
SCHEMBL31489209 0.70 MAPT (0.32) KDM4E
SCHEMBL27038245 0.69 NUDT1 (0.56) PIK3CGPIK3CDNUDT1CALCAGPR119
SCHEMBL20844717 0.67 NUDT1 (0.38) PIK3CGNUDT1KDM4EALDH1A1GLA
SCHEMBL7870538 0.63 JAK1 (0.42) PIK3CGPIK3CDNUDT1KDM4EALDH1A1
SCHEMBL31489336 0.62 PIK3CG (0.38) PIK3CGPIK3CDKDM4EALDH1A1
SCHEMBL2254006 0.62 NUDT1 (0.57) PIK3CGNUDT1KDM4EALDH1A1CHEK1
SCHEMBL30927826 0.62 NUDT1 (0.56) NUDT1KDM4EALDH1A1CHEK1MET
SCHEMBL2789371 0.60 KDM4E (0.40) PIK3CGPIK3CDNUDT1KDM4EALDH1A1
SCHEMBL2773213 0.59 NUDT1 (0.55) PIK3CGNUDT1CALCAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed