Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428961 | 0.89 | NR4A2 (0.57) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL4625769 | 0.86 | KDM4E (0.51) | NR4A2ALDH1A1KMT2AKDM4ELMNA | |
| SCHEMBL9317997 | 0.81 | NR4A2 (0.69) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL3263245 | 0.80 | ALOX5 (0.60) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL3261338 | 0.80 | NR4A2 (0.56) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL4624897 | 0.79 | NR4A2 (0.44) | NR4A2ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL3263240 | 0.78 | NR4A2 (0.53) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL8810246 | 0.77 | NR4A2 (0.63) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL3263959 | 0.76 | NR4A2 (0.51) | NR4A2ALOX5ALDH1A1KMT2AKDM4E | |
| SCHEMBL5137730 | 0.75 | NR4A2 (1.00) | NR4A2ALOX5ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097135-B1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 2008-05-07 | — | — | EP | claimed |
| US-6946565-B2 | Process for the preparation of an indole derivative | SMITHKLINE BEECHAM PLC (GB) | 2005-09-20 | — | — | US | claimed |
| US-20040192911-A1 | Process for the preparation of an indole derivative | SMITHKLINE BEECHAM P.L.C. | 2004-09-30 | — | — | US | claimed |
| EP-1097136-B1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 2003-10-22 | — | — | EP | claimed |
| US-6583294-B2 | Reacting 3-chloro-3-carboxylate indole with 3-chloropropanol in presence of such as trichloroacetic acid to produce methyl 2-(3-chloropropoxy)-indole-3-carboxylate in high yield | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-24 | — | — | US | claimed |
| US-20030114684-A1 | Preparation of methyl 2-(3-chloropropoxy)indole-3-carboxylate by reacting 3-chloro-3-carboxylate indole compound with 3-chloropropanol in presence of acid having pKa of 0-2 | SMITHKLINE BEECHAM PLC | 2003-06-19 | — | — | US | claimed |
| US-20030083506-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM P.L.C. | 2003-05-01 | — | — | US | claimed |
| US-20020091271-A1 | Process for the preparation of an indole derivative | SMITHKLINE BEECHAM PLC | 2002-07-11 | — | — | US | claimed |
| EP-1097136-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | SMITHKLINE BEECHAM PLC (GB) | 2001-05-09 | — | — | EP | claimed |
| WO-2000003984-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-27 | — | — | WO | claimed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| EP-1701951-B1 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | SERODUS AS (NO) | 2010-02-10 | — | — | EP | disclosed |
| US-20090029979-A1 | 5-HTX MODULATORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2009-01-29 | — | — | US | disclosed |
| WO-2000003984-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-27 | — | — | WO | disclosed |
| WO-2000003984-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-27 | — | — | WO | disclosed |
| CN-1233250-A | Process for the preparation of N-[cl-nButyl-4-piperidyl) methyl-3,4-dihydro-2h-[1,3] oxazino [3,2-a] indole-10-carboxamide and salts and intermediates in the process | SMITHKLINE BEECHAM PLC (GB) | 1999-10-27 | — | — | CN | disclosed |
| EP-0922048-A1 | PROCESS FOR THE PREPARATION OF N- (1-?n BUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H- 1,3] OXAZINO 3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998007728-A1 | PROCESS FOR THE PREPARATION OF N-[(1-nBUTYL-4-PIPERIDYL)METHYL] -3,4-DIHYDRO -2H-[1,3] OXAZINO[3,2-a] INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029979-A1 | 5-HTX MODULATORS | HTR7, HTR5A, HTR2C | NR4A2 808/4885ALOX5 357/4885ALDH1A1 3581/4885 |
| US-20030083506-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | PRKD3, COMT, IDO1 | NR4A2 3632/4885ALOX5 1629/4885ALDH1A1 1418/4885 |
| US-20040192911-A1 | Process for the preparation of an indole derivative | PRKD3, COMT, IDO1 | NR4A2 3632/4885ALOX5 1629/4885ALDH1A1 1418/4885 |
| US-20030114684-A1 | Preparation of methyl 2-(3-chloropropoxy)indole-3-carboxylate by reacting 3-chloro-3-carboxylate indole compound with 3-chloropropanol in presence of acid having pKa of 0-2 | HTR3C, HTR3A, PRKD3 | NR4A2 2945/4885ALOX5 1455/4885ALDH1A1 1653/4885 |
| US-20020091271-A1 | Process for the preparation of an indole derivative | PRKD3, COMT, IDO1 | NR4A2 3632/4885ALOX5 1629/4885ALDH1A1 1418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.