Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.78 |
| ▸ | ACHE | P22303 | 6/20 | 0.62 |
| ▸ | BCHE | P06276 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778956 | 0.84 | SIGMAR1 (0.71) | HTR4ACHEBCHEHTTMAPK14 | |
| SCHEMBL8287823 | 0.84 | HTR4 (1.00) | HTR4GRIN2B | |
| SCHEMBL8422190 | 0.84 | HTR4 (0.72) | HTR4MAPTGRIN2B | |
| SCHEMBL7429744 | 0.83 | HTR4 (0.80) | HTR4 | |
| SCHEMBL9572763 | 0.81 | ALDH1A1 (0.68) | HTR4ACHEBCHEHTTMAPK14 | |
| SCHEMBL24076757 | 0.81 | GRIN2B (0.72) | HTR4GRIN2B | |
| SCHEMBL7301492 | 0.80 | HTR4 (0.73) | HTR4ACHEBCHEHTTMAPK14 | |
| SCHEMBL8287834 | 0.80 | HTR4 (0.67) | HTR4 | |
| SCHEMBL16321074 | 0.80 | GSK3B (0.75) | HTR4ACHEHDAC3HDAC4HDAC1 | |
| SCHEMBL8285569 | 0.78 | HTR4 (1.00) | HTR4ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| US-7834010-B2 | Modulators of peripheral 5-HT receptors | SERODUS AS (NO) | 2010-11-16 | — | — | US | disclosed |
| EP-1701951-B1 | MODULATORS OF PERIPHERAL 5-HT RECEPTORS | SERODUS AS (NO) | 2010-02-10 | — | — | EP | disclosed |
| US-20090029979-A1 | 5-HTX MODULATORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2009-01-29 | — | — | US | disclosed |
| US-20090029979-A1 | 5-HTX MODULATORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2009-01-29 | — | — | US | disclosed |
| US-20090029979-A1 | 5-HTX MODULATORS | BIO-MEDISINSK INNOVASJON AS (NO) | 2009-01-29 | — | — | US | disclosed |
| EP-1902044-A1 | 5-HTX MODULATORS | Bio Medisinsk Innovasjon AS (NO) | 2008-03-26 | — | — | EP | disclosed |
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | BIO-MEDISINSK INNOVASJON (NO) | 2007-11-01 | — | — | US | disclosed |
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | BIO-MEDISINSK INNOVASJON (NO) | 2007-11-01 | — | — | US | disclosed |
| EP-0630376-B1 | CONDENSED INDOLE DERIVATIVES AS 5-HT4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-02 | — | — | EP | disclosed |
| US-5852014-A | Condensed indole derivatives as 5HT4 -receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-12-22 | — | — | US | disclosed |
| EP-0712406-B1 | CONDENSED INDOLE DERIVATIVES AS 5-HT 4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | EP | disclosed |
| US-5705498-A | Piperidine derivatives as 5-HT4 receptor antagonists | SMITHKLINE BEECHAM PLC. (GB) | 1998-01-06 | — | — | US | disclosed |
| EP-0712406-A1 | CONDENSED INDOLE DERIVATIVES AS 5-HT 4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-22 | — | — | EP | disclosed |
| EP-0667867-A1 | PIPERIDINE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1995004737-A1 | CONDENSED INDOLE DERIVATIVES AS 5-HT4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-16 | — | — | WO | disclosed |
| EP-0630376-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT 4?-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1994010174-A1 | PIPERIDINE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-05-11 | — | — | WO | disclosed |
| WO-1993018036-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029979-A1 | 5-HTX MODULATORS | HTR7, HTR5A, HTR2C | HTR4 9/4885ACHE 358/4885BCHE 1341/4885 |
| US-20070254874-A1 | Modulators of Preripheral 5-Ht Receptors | HTR4, HTR5A, HTR6 | HTR4 1/4885ACHE 782/4885BCHE 1710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.