Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | HPGDS | O60760 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208812 | 0.91 | HPGDS (0.66) | HPGDNPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL6793430 | 0.85 | HPGDS (0.83) | HPGDNPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL8540384 | 0.82 | L3MBTL1 (0.57) | HPGDNPC1RAB9AL3MBTL1MAPT | |
| SCHEMBL23041066 | 0.82 | NPC1 (0.65) | HPGDNPC1RAB9ATSHRHPGDS | |
| SCHEMBL12039117 | 0.81 | HPGDS (0.61) | HPGDNPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL15227842 | 0.81 | L3MBTL1 (0.68) | HPGDNPC1RAB9AL3MBTL1MAPT | |
| SCHEMBL15988676 | 0.81 | MAPT (0.78) | HPGDNPC1RAB9ATSHRL3MBTL1 | |
| SCHEMBL2760408 | 0.80 | HPGDS (0.69) | HPGDNPC1RAB9ATSHRHPGDS | |
| SCHEMBL11306574 | 0.80 | HPGDS (0.69) | HPGDNPC1RAB9ATSHRHPGDS | |
| SCHEMBL11449717 | 0.80 | HPGD (0.69) | HPGDNPC1RAB9ATSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750048-B2 | GPR40 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-06 | — | — | US | disclosed |
| US-7750048-B2 | GPR40 agonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-06 | — | — | US | disclosed |
| EP-1423387-B1 | PHOTOCHROMIC BIS-NAPHTHOPYRAN COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INT (FR) | 2010-03-17 | — | — | EP | disclosed |
| US-20080176912-A1 | GPR40 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-24 | — | — | US | disclosed |
| US-20080176912-A1 | GPR40 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-24 | — | — | US | disclosed |
| US-7361668-B2 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors | UCB, S.A. (BE) | 2008-04-22 | — | — | US | disclosed |
| US-6939007-B2 | Photochromic bis-naphthopyran compounds and methods for their manufacture | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2005-09-06 | — | — | US | disclosed |
| US-20050020660-A1 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors | UCB, S.A. (BE) | 2005-01-27 | — | — | US | disclosed |
| EP-1438309-A1 | QUINUCLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS M2 AND/OR M3 MUSCARINIC RECEPTOR INHIBITORS | UCB, S.A. (BE) | 2004-07-21 | — | — | EP | disclosed |
| US-6747145-B2 | COUPLING A PROPARGYL ALCOHOL WITH A NAPHTHOL IN THE PRESENCE OF A CATALYTIC AMOUNT OF AN ACID, A SOLVENT AND 3 ANGSTROM MOLECULAR SIEVE TO GENERATE NAPHTHOPYRAN COMPOUND | JOHNSON & JOHNSON VISION CARE, INC. | 2004-06-08 | — | — | US | disclosed |
| US-4685783-A | Polychromic tetracyclo-spiro-adamatylidene derivatives, and polychromic lens incorporating said compounds | THE PLESSEY COMPANY P.L.C. (GB) | 1987-08-11 | — | — | US | disclosed |
| EP-0140540-A2 | Photochromic compounds and their uses in photoreactive lenses | THE PLESSEY COMPANY plc (GB) | 1985-05-08 | — | — | EP | disclosed |
| EP-0007678-B1 | OXIME ETHERS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ACF CHEMIEFARMA NV (NL) | 1983-03-30 | — | — | EP | disclosed |
| US-4352804-A | ANTIULCER AGENTS, GASTROINTESTINAL DISORDERS | ACF CHEMIEFARMA NV (NL) | 1982-10-05 | — | — | US | disclosed |
| EP-0046446-A1 | Polyazaheterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1982-02-24 | — | — | EP | disclosed |
| US-4297359-A | ANTISECRETORY AGENTS; GASTROINTESTINAL DISORDERS | ACF CHEMIEFARMA NV (NL) | 1981-10-27 | — | — | US | disclosed |
| US-4235896-A | Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the same | ORCHIMED S.A. (CH) | 1980-11-25 | — | — | US | disclosed |
| EP-0007678-A1 | Oxime ethers, their preparation and pharmaceutical compositions containing them | ACF CHEMIEFARMA NV (NL) | 1980-02-06 | — | — | EP | disclosed |
| EP-0007679-A1 | Oxime ethers, processes for their manufacture and pharmaceutical compositions thereof | ACF CHEMIEFARMA NV (NL) | 1980-02-06 | — | — | EP | disclosed |
| US-4179515-A | HYPOLIPEMIC, HYPOCHOLESTEROLEMIC, CHOLAGOGIC | ORCHIMED S. A. (CH) | 1979-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176912-A1 | GPR40 AGONISTS | GPR119, GPR65, GPR55 | HPGD 1362/4885NPC1 182/4885RAB9A 2714/4885 |
| US-20050020660-A1 | Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors | CHRM2, CHRM3, CHRM1 | HPGD 1363/4885NPC1 4468/4885RAB9A 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.