Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071662 | 0.94 | MTNR1A (0.42) | MTNR1AMTNR1BHTR2AL3MBTL1ALDH1A1 | |
| SCHEMBL2071508 | 0.91 | HTR2A (0.43) | MTNR1AMTNR1BHTR2AALDH1A1HTR2C | |
| Ammonia Solution, Strong SCHEMBL5199276 | 0.79 | HTR2A (0.43) | MTNR1AMTNR1BHTR2AALDH1A1HTR2C | |
| SCHEMBL13451646 | 0.77 | SLC6A2 (0.39) | HTR2AALDH1A1HTR1AKDM4EMAPT | |
| SCHEMBL2073706 | 0.76 | HDAC3 (0.44) | MTNR1AMTNR1BHTR2AALDH1A1HPGD | |
| SCHEMBL3160107 | 0.75 | MTNR1A (0.33) | MTNR1AMTNR1BHTR2AL3MBTL1HTR2C | |
| SCHEMBL3151911 | 0.73 | SLC6A2 (0.44) | MTNR1AMTNR1BHTR2AALDH1A1HPGD | |
| SCHEMBL1714010 | 0.73 | MTNR1A (0.46) | MTNR1AMTNR1BHTR2AL3MBTL1ALDH1A1 | |
| SCHEMBL1714014 | 0.73 | MTNR1A (0.46) | MTNR1AMTNR1BHTR2AL3MBTL1ALDH1A1 | |
| SCHEMBL2074732 | 0.72 | CYP2D6 (0.57) | MTNR1AHTR2AALDH1A1HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756054-B1 | 3-AMINO-1-ARYLPROPYL INDOLES AS MONOAMINE REUPTAKE INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-03-31 | — | — | EP | disclosed |
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | ROCHE PALO ALTO LLC | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025467-A1 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors | TPH1, HTR1A, HTR3A | MTNR1A 40/4885MTNR1B 56/4885HTR2A 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.