Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.57 |
| ▸ | MMP9 | P14780 | 10/20 | 0.57 |
| ▸ | MMP2 | P08253 | 7/20 | 0.57 |
| ▸ | MMP8 | P22894 | 6/20 | 0.57 |
| ▸ | MMP12 | P39900 | 6/20 | 0.57 |
| ▸ | MMP14 | P50281 | 5/20 | 0.57 |
| ▸ | MMP16 | P51512 | 5/20 | 0.57 |
| ▸ | MMP3 | P08254 | 5/20 | 0.57 |
| ▸ | MMP1 | P03956 | 5/20 | 0.48 |
| ▸ | PNLIP | P16233 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316419 | 0.85 | LTA4H (0.46) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL315789 | 0.71 | MMP2 (0.56) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL8933405 | 0.70 | KEAP1 (0.41) | LMNACA1CA2NPC1RAB9A | |
| SCHEMBL29587251 | 0.69 | LTA4H (0.48) | LMNACA1CA2MEN1KMT2A | |
| SCHEMBL20955819 | 0.69 | LTA4H (0.48) | LMNACA1CA2MEN1KMT2A | |
| SCHEMBL974430 | 0.69 | GAA (0.67) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL2070079 | 0.69 | SLC6A3 (0.46) | LMNAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL10515711 | 0.67 | MEN1 (0.65) | MMP13MMP9MMP2MMP8MMP12 | |
| SCHEMBL6395440 | 0.67 | CA4 (0.54) | LMNACA1CA2KMT2ANPC1 | |
| SCHEMBL12772116 | 0.67 | ALDH1A1 (0.49) | LMNACA1CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | claimed |
| JP-2009545556-A | — | — | 2009-12-24 | — | — | JP | claimed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | claimed |
| EP-2059500-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | Bracco Imaging S.p.A (IT) | 2009-05-20 | — | — | EP | claimed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | claimed |
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-8093386-B2 | Thioaryl substituted inhibitors of zinc proteases and their use | BRACCO IMAGING S.P.A (IT) | 2012-01-10 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | BRACCO IMAGING SPA (IT) | 2009-09-24 | — | — | US | disclosed |
| EP-2059500-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | Bracco Imaging S.p.A (IT) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008015139-A2 | INHIBITORS OF ZINC PROTEASES THIOARYL SUBSTITUTED AND THEIR USE | BRACCO IMAGING SPA (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239829-A1 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE | SERPINB1, ZFX, MMP2 | MMP13 68/4885MMP9 8/4885MMP2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.