Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.41 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31326337 | 0.92 | HTR2A (0.47) | CHEK1HTR6CYP2C9HDAC1HDAC3 | |
| Fumaric Acid SCHEMBL31636020 | 0.87 | HTR2A (0.47) | CHEK1HTR6HTR2AMPOCYP3A4 | |
| Fumaric Acid SCHEMBL31635950 | 0.86 | HTR6 (0.56) | CHEK1HTR6CYP2C9HDAC1HDAC3 | |
| Fumaric Acid SCHEMBL31635980 | 0.80 | KMT2A (0.52) | CHEK1HTR6CYP2C9HDAC1HDAC3 | |
| SCHEMBL31326349 | 0.78 | CYP3A4 (0.56) | HTR6CYP2C9HDAC1HDAC3HDAC2 | |
| SCHEMBL31326330 | 0.77 | HTR2A (0.54) | CHEK1HTR6HTR2AMPOCYP3A4 | |
| SCHEMBL31326343 | 0.76 | MPO (0.47) | HTR6CYP2C9HDAC1HDAC3HDAC2 | |
| SCHEMBL31326334 | 0.76 | HTR6 (0.49) | CHEK1HTR6CYP2C9HTR2AMPO | |
| Fumaric Acid SCHEMBL31635972 | 0.73 | HTR2A (0.41) | HTR6CYP2C9HTR2ACYP3A4HTR1A | |
| Fumaric Acid SCHEMBL31635977 | 0.73 | SMYD2 (0.39) | HTR6MPOHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | Psylo Pty Ltd (AU) | 2025-11-27 | — | — | US | disclosed |
| US-12415804-B2 | Compounds for activating a serotonin receptor | Psylo Pty Ltd (AU) | 2025-09-16 | — | — | US | disclosed |
| US-20250206739-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206739-A1 | Compounds | NLN, SLC18A2, PYGB | HTR2A 94/4885DRD2 226/4885KMT2A 2336/4885 |
| US-12415804-B2 | Compounds for activating a serotonin receptor | HTR2C, HTR6, HTR2A | HTR2A 3/4885DRD2 96/4885KMT2A 3246/4885 |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | HTR2C, HTR2A, HTR6 | HTR2A 2/4885DRD2 71/4885KMT2A 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.