Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.47 |
| ▸ | KMT2A known ✓ | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.47 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31326335 | 0.92 | HTR2A (0.55) | HTR2AHTR2CKMT2ASMN1; SMN2GAA | |
| Fumaric Acid SCHEMBL31636020 | 0.87 | HTR2A (0.47) | HTR2AHTR2CKMT2AMEN1KDM4E | |
| Fumaric Acid SCHEMBL31635942 | 0.84 | KMT2A (0.55) | HTR2AHTR2CKMT2AMEN1KDM4E | |
| SCHEMBL31326369 | 0.80 | KMT2A (0.53) | HTR2AHTR2CKMT2ASMN1; SMN2GAA | |
| Fumaric Acid SCHEMBL31635996 | 0.79 | HTR6 (0.59) | HTR2AHTR2CKMT2AMEN1HTR6 | |
| SCHEMBL31326330 | 0.77 | HTR2A (0.54) | HTR2AHTR2CKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL31326343 | 0.76 | MPO (0.47) | HTR2AKMT2ASMN1; SMN2HTR6MAPT | |
| SCHEMBL31326317 | 0.74 | KMT2A (0.64) | HTR2AHTR2CKMT2AMTNR1AMTNR1B | |
| Fumaric Acid SCHEMBL31635984 | 0.73 | CHEK1 (0.44) | HTR2AKMT2AMEN1SMN1; SMN2HTR6 | |
| SCHEMBL5351287 | 0.72 | ALDH1A1 (0.60) | KMT2AMEN1ALDH1A1GAAMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | Psylo Pty Ltd (AU) | 2025-11-27 | — | — | US | disclosed |
| US-12415804-B2 | Compounds for activating a serotonin receptor | Psylo Pty Ltd (AU) | 2025-09-16 | — | — | US | disclosed |
| US-20250206739-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206739-A1 | Compounds | NLN, SLC18A2, PYGB | HTR2A 94/4885HTR2C 23/4885KMT2A 2336/4885 |
| US-12415804-B2 | Compounds for activating a serotonin receptor | HTR2C, HTR6, HTR2A | HTR2A 3/4885HTR2C 1/4885KMT2A 3246/4885 |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | HTR2C, HTR2A, HTR6 | HTR2A 2/4885HTR2C 1/4885KMT2A 3086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.