Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | USP7 | Q93009 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 3/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31637372 | 0.94 | USP7 (0.41) | FAAHGPR119USP7JAK2JAK1 | |
| SCHEMBL31637295 | 0.88 | FEN1 (0.43) | BACE1JAK2JAK1BRD4HCAR1 | |
| SCHEMBL31637282 | 0.85 | BRD4 (0.40) | BRD4 | |
| SCHEMBL31637365 | 0.82 | USP1 (0.40) | GPR119JAK2JAK1CDK9 | |
| SCHEMBL31637159 | 0.82 | TGFBR1 (0.44) | FAAHBACE1GPR119KDM4EPKM | |
| SCHEMBL31637176 | 0.79 | YTHDC1 (0.37) | CDK9 | |
| SCHEMBL12537437 | 0.78 | YTHDC1 (0.46) | FAAHBACE1GPR119USP7KDM4E | |
| SCHEMBL4768843 | 0.77 | KDM4E (0.51) | FAAHBACE1GPR119USP7KDM4E | |
| SCHEMBL12984965 | 0.76 | CDK9 (0.43) | FAAHBACE1GPR119USP7KDM4E | |
| SCHEMBL31637347 | 0.76 | CYP2D6 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250206745-A1 | PYRROLOPYRIDAZINE DERIVATIVES AND RELATED USES | NODTHERA LTD (GB) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206745-A1 | PYRROLOPYRIDAZINE DERIVATIVES AND RELATED USES | IL1B, NLRP3, NLRP1 | FAAH 3308/4885BACE1 1299/4885GPR119 3657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.