Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.40 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31678785 | 0.88 | PTGS1 (0.53) | PTGS1PTGS2PRMT6SGK1CKS1B | |
| SCHEMBL30862914 | 0.72 | ALDH1A1 (0.41) | PTGS1PTGS2SGK1CKS1BSKP2 | |
| SCHEMBL6850398 | 0.72 | HDAC4 (0.56) | PTGS1PTGS2SGK1CKS1BSKP2 | |
| SCHEMBL31678837 | 0.72 | PTGS1 (0.43) | PTGS1PTGS2PRMT6CKS1BSKP2 | |
| SCHEMBL1099375 | 0.69 | HDAC4 (0.47) | PTGS1PTGS2PRMT6SGK1HDAC4 | |
| SCHEMBL21590270 | 0.69 | CA1 (0.53) | SGK1HDAC4MAP2K4TDP1BRPF1 | |
| SCHEMBL3980159 | 0.69 | CA1 (0.53) | SGK1HDAC4MAP2K4BRPF1JAK2 | |
| SCHEMBL3088517 | 0.69 | SGK1 (0.51) | PRMT6SGK1HDAC4MAP2K4BRPF1 | |
| SCHEMBL28207342 | 0.69 | HDAC4 (0.47) | PTGS1PTGS2PRMT6SGK1HDAC4 | |
| SCHEMBL14830078 | 0.69 | MAP2K4 (0.56) | SGK1HDAC4MAP2K4BRPF1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270200-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2025-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250270200-A1 | CTPS1 INHIBITORS AND USES THEREOF | CTPS1, CTPS2, ECHS1 | PTGS1 1724/4885PTGS2 2086/4885PRMT6 2024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.