Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176926 | 0.86 | MEN1 (0.37) | MAPK1OPRM1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL27714409 | 0.82 | CYP2A6 (0.38) | CSNK2A1 | |
| SCHEMBL11412295 | 0.80 | ABCC9 (0.33) | ALDH1A1POLBABCC9ABCC8KCNJ11 | |
| SCHEMBL15173341 | 0.77 | MAPK1 (0.46) | MAPK1OPRM1LMNATSHRHPGD | |
| SCHEMBL1993769 | 0.76 | MAPK1 (0.48) | MAPK1OPRM1LMNATSHRHPGD | |
| SCHEMBL3183675 | 0.76 | SIGMAR1 (0.44) | HPGDALDH1A1MEN1KMT2APOLB | |
| SCHEMBL8293173 | 0.76 | MAPK1 (0.44) | MAPK1OPRM1LMNATSHRHPGD | |
| SCHEMBL3182185 | 0.74 | GABRA1 (0.41) | MAPK1LMNATSHRHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1584720 | 0.74 | MAPK1 (0.47) | MAPK1OPRM1LMNATSHRHPGD | |
| SCHEMBL6901376 | 0.73 | ALDH1A1 (0.44) | TSHRALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652062-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH LLC (US) | 2010-01-26 | — | — | US | disclosed |
| CN-101287461-A | Use of 5-amido-1h-pyrrole-2-nitrile derivative as progesterone receptor modulators | WYETH CORP (US) | 2008-10-15 | — | — | CN | disclosed |
| CN-101233103-A | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH CORP (US) | 2008-07-30 | — | — | CN | disclosed |
| EP-1909785-A2 | USE OF PROGESTERONE RECEPTOR MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910284-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | Wyeth (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2008-03-13 | — | — | US | disclosed |
| US-7297713-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| WO-2007016211-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016385-A2 | USE OF SUBSTITUTED 5-AMINO-1H-PYRROLE-2-CARBONITRILE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027201-A1 | Use of progesterone receptor modulators | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | PGR, GNRHR, PGRMC1 | MAPK1 437/4885OPRM1 246/4885LMNA 4115/4885 |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | PGR, PGRMC1, PGRMC2 | MAPK1 438/4885OPRM1 266/4885LMNA 4065/4885 |
| US-20070027201-A1 | Use of progesterone receptor modulators | GNRHR, PGR, FSHR | MAPK1 874/4885OPRM1 301/4885LMNA 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.