Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706241 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA4CHEK1CHRNB4CHRNA3 | |
| SCHEMBL31706212 | 0.85 | CHEK1 (0.46) | CHRNB2CHRNA4CHEK1CHRNB4CHRNA3 | |
| SCHEMBL31705857 | 0.82 | ATM (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL31706868 | 0.82 | ATM (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 | |
| Lithium Ion SCHEMBL31705607 | 0.79 | PLOD2 (0.48) | CHRNB2CHRNA4ALDH1A1CYP11B2MKNK1 | |
| Lithium Ion SCHEMBL31706878 | 0.75 | TDP1 (0.50) | CHRNB2CHRNA4ALDH1A1MAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31704582 | 0.75 | TDP1 (0.50) | CHRNB2CHRNA4ALDH1A1MAPTSMN1; SMN2 | |
| Lithium Ion SCHEMBL31706365 | 0.72 | CHRNB2 (0.41) | CHRNB2CHRNA4ALDH1A1LMNAMAPT | |
| Lithium Ion SCHEMBL31705412 | 0.70 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 | |
| Lithium Ion SCHEMBL31705364 | 0.70 | CHRNB2 (0.37) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |