Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228363 | 0.84 | ALDH1A1 (0.52) | MAPTALDH1A1KCNA3SMN1; SMN2KDM4E | |
| SCHEMBL30228405 | 0.73 | CA9 (0.56) | MAPTALDH1A1KCNA3TP53CYP3A4 | |
| SCHEMBL30231539 | 0.73 | IGLV6-57 (0.44) | MAPTALDH1A1KCNA3SMN1; SMN2TP53 | |
| SCHEMBL17847645 | 0.73 | ALDH1A1 (0.38) | MAPTALDH1A1KCNA3SMN1; SMN2HSD11B1 | |
| SCHEMBL4929225 | 0.73 | ALDH1A1 (0.43) | MAPTALDH1A1TP53CYP3A4HSD11B1 | |
| SCHEMBL1358798 | 0.71 | KDM4E (0.72) | MAPTALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL30228286 | 0.71 | KCNA3 (0.47) | MAPTALDH1A1KCNA3CYP3A4KDM4E | |
| SCHEMBL9262604 | 0.71 | MAOB (0.60) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL30228654 | 0.71 | KCNA3 (0.44) | MAPTALDH1A1KCNA3SMN1; SMN2CYP3A4 | |
| SCHEMBL30228422 | 0.70 | KCNA3 (0.46) | MAPTALDH1A1KCNA3CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | MAPT 716/4885ALDH1A1 3178/4885KCNA3 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.