Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | MC3R | P41968 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31712857 | 0.79 | TSHR (0.42) | PARP1PI4K2ACHEK1TSHRPDE4B | |
| SCHEMBL31712899 | 0.75 | SIRT6 (0.37) | LCKSIRT6CHEK1ADORA3TSHR | |
| SCHEMBL29875709 | 0.74 | LCK (0.35) | LCKSIRT6PRF1CHEK1ADORA3 | |
| SCHEMBL31712846 | 0.68 | LCK (0.40) | LCKSIRT6ADORA3TSHRMC4R | |
| SCHEMBL24468332 | 0.68 | IKBKE (0.33) | PARP1 | |
| SCHEMBL18248727 | 0.66 | NOS3 (0.52) | LCKSIRT6ADORA3TSHRMC4R | |
| SCHEMBL19641430 | 0.65 | SIRT6 (0.40) | LCKSIRT6PRF1CHEK1ADORA3 | |
| SCHEMBL5299145 | 0.65 | TSHR (0.49) | LCKMAP3K14SIRT6CHEK1ADORA3 | |
| SCHEMBL30036680 | 0.65 | SIRT6 (0.40) | LCKSIRT6PRF1CHEK1ADORA3 | |
| SCHEMBL16447402 | 0.65 | LCK (0.40) | LCKPI4K2ASIRT6ADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-B1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC (US) | 2025-10-29 | — | — | EP | claimed |