Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.72 |
| ▸ | RAB9A | P51151 | 7/20 | 0.72 |
| ▸ | SCD | O00767 | 1/20 | 0.65 |
| ▸ | AQP4 | P55087 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | METAP1 | P53582 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrobenzene SCHEMBL27714762 | 0.87 | MAPT (0.68) | NPC1RAB9ASCDLMNAKCNK3 | |
| SCHEMBL14082512 | 0.85 | NPC1 (0.63) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL995829 | 0.84 | NPC1 (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27594584 | 0.83 | NPC1 (0.97) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL6919419 | 0.82 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2628996 | 0.81 | NPC1 (0.76) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL6918262 | 0.80 | GRM5 (0.59) | NPC1RAB9ASCDSMN1; SMN2MEN1 | |
| SCHEMBL15116297 | 0.80 | ALDH1A1 (0.81) | LMNAMEN1KMT2AL3MBTL1RECQL | |
| SCHEMBL16562033 | 0.79 | SCD (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL3178559 | 0.78 | AQP4 (1.00) | NPC1RAB9ASCDAQP4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | claimed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | claimed |
| CN-107501258-A | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2017-12-22 | — | — | CN | claimed |
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | claimed |
| US-20240166651-A1 | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-05-23 | — | — | US | disclosed |
| CN-107501258-B8 | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 青岛大学附属医院 | 2018-10-16 | — | — | CN | disclosed |
| CN-107501258-B8 | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 青岛大学附属医院 | 2018-10-16 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-107501258-B | Thiazolyl nicotinamide compound and application thereof in preparation of anti-allergic and anti-asthma medicines | 刘双伟 | 2018-08-28 | — | — | CN | disclosed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | disclosed |
| CN-108299418-A | A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma | 刘双伟 | 2018-07-20 | — | — | CN | disclosed |
| WO-2016102969-A1 | INHIBITION OF HAIR GROWTH | THE UNIVERSITY OF MANCHESTER (GB) | 2016-06-30 | — | — | WO | disclosed |
| US-7659312-B2 | Inhibitors of Aquaporin 4, methods and uses thereof | NIIGATA UNIVERSITY (JP) | 2010-02-09 | — | — | US | disclosed |
| US-7659312-B2 | Inhibitors of Aquaporin 4, methods and uses thereof | NIIGATA UNIVERSITY (JP) | 2010-02-09 | — | — | US | disclosed |
| US-7659312-B2 | Inhibitors of Aquaporin 4, methods and uses thereof | NIIGATA UNIVERSITY (JP) | 2010-02-09 | — | — | US | disclosed |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | NIIGATA UNIVERSITY (JP) | 2007-12-06 | — | — | US | disclosed |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | NIIGATA UNIVERSITY (JP) | 2007-12-06 | — | — | US | disclosed |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | NIIGATA UNIVERSITY (JP) | 2007-12-06 | — | — | US | disclosed |
| WO-2006129257-A2 | KETOLIDE DERIVATIVES AS ANTIBACTERIAL AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240166651-A1 | HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS | TYK2, JAK3, JAK1 | NPC1 4516/4885RAB9A 3268/4885SCD 3940/4885 |
| US-20070281978-A1 | INHIBITORS OF AQUAPORIN 4, METHODS AND USES THEREOF | AQP4, AQP1, AQP3 | NPC1 276/4885RAB9A 2079/4885SCD 4153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.