Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.41 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057460 | 0.88 | TTR (0.60) | CYP1A2CYP2A6TTRKMT2AALDH1A1 | |
| SCHEMBL703189 | 0.87 | TTR (0.61) | CYP1A2TTRKMT2AALDH1A1MEN1 | |
| SCHEMBL29409575 | 0.87 | TTR (0.61) | CYP1A2TTRKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL28234846 | 0.86 | TTR (0.58) | CYP1A2CYP2A6TTRKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL11157253 | 0.84 | TTR (0.59) | CYP1A2TTRKMT2AALDH1A1MEN1 | |
| SCHEMBL7710380 | 0.84 | TTR (0.59) | CYP1A2TTRKMT2AALDH1A1MEN1 | |
| SCHEMBL10925668 | 0.83 | CYP1A2 (0.59) | CYP1A2CYP2A6POLBFABP4KMT2A | |
| SCHEMBL639819 | 0.81 | CYP1A2 (0.56) | CYP1A2CYP2A6POLBFABP4KMT2A | |
| SCHEMBL17212139 | 0.80 | AURKA (0.53) | CYP1A2CYP2A6POLBFABP4TTR | |
| SCHEMBL17441666 | 0.79 | LDHA (0.62) | CYP1A2CYP2A6POLBFABP4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454289-B | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR | 2012-07-04 | — | — | CN | claimed |
| EP-2007729-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2012-06-27 | — | — | EP | claimed |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-08-20 | — | — | US | claimed |
| CN-101454289-A | Substituted tetrahydroisoquinoline compounds, their preparation and use in medicine | ESTEVE LABOR DR (ES) | 2009-06-10 | — | — | CN | claimed |
| EP-2007729-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-12-31 | — | — | EP | claimed |
| WO-2007107373-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE S.A. (DE) | 2007-09-27 | — | — | WO | claimed |
| EP-0946539-B1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 2003-08-13 | — | — | EP | claimed |
| US-20030069233-A1 | Sulphonamide derivatives, process for their preparation, and their use as medicaments | SMITHKLINE BEECHAM P.L.C. | 2003-04-10 | — | — | US | claimed |
| CN-1246116-A | Sulfonamide derivatives, process for their preparation and their use as medicaments | SMITHKLINE BEECHAM PLC (GB) | 2000-03-01 | — | — | CN | claimed |
| EP-0946539-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027081-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-25 | — | — | WO | claimed |
| US-9541850-B2 | Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2017-01-10 | — | — | US | disclosed |
| US-9541850-B2 | Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus | CANON KABUSHIKI KAISHA (JP) | 2017-01-10 | — | — | US | disclosed |
| US-20150309426-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2015-10-29 | — | — | US | disclosed |
| US-20150309426-A1 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS | CANON KABUSHIKI KAISHA (JP) | 2015-10-29 | — | — | US | disclosed |
| EP-0022880-B1 | PROCESS FOR THE SEPARATION OF LEUCINE, ISOLEUCINE AND VALINE | MAGGI A.G. (CH) | 1982-04-21 | — | — | EP | disclosed |
| US-4263450-A | PRECIPITATION AS HYDROCHLORIDE | SOCIETE D'ASSISTANCE TECHNIQUE POUR PRODUITS NESTLE S.A. (CH) | 1981-04-21 | — | — | US | disclosed |
| EP-0022880-A1 | Process for the separation of leucine, isoleucine and valine | MAGGI A.G. (CH) | 1981-01-28 | — | — | EP | disclosed |
| US-4091013-A | Process for preparing 1-amino-naphthalene-7-sulphonic acid | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-23 | — | — | US | disclosed |
| US-3987092-A | PROCESS FOR THE PREPARATION OF A SALT OF OPTICALLY ACTIVE LYSINE | STAMICARBON N.V. (NL) | 1976-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069233-A1 | Sulphonamide derivatives, process for their preparation, and their use as medicaments | TPMT, MPST, STS | CYP1A2 1575/4885CYP2A6 432/4885POLB 3308/4885 |
| US-20090209528-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUND, THEIR PREPARATION AND USE IN MEDICAMENTS | HTR6, HTR5A, HTR7 | CYP1A2 88/4885CYP2A6 26/4885POLB 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.