Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096949 | 0.88 | POLB (0.43) | MEN1LMNAKMT2APRKCAPOLB | |
| Hydrochloric Acid SCHEMBL3506265 | 0.86 | POLB (0.42) | MEN1LMNAKMT2APRKCAPOLB | |
| SCHEMBL16174088 | 0.78 | PRKCA (0.33) | PRKCA | |
| SCHEMBL18274690 | 0.77 | ALDH1A1 (0.35) | POLBGAANPSR1 | |
| Tromethamine SCHEMBL6327657 | 0.77 | NAAA (0.42) | MEN1LMNAKMT2AGAA | |
| SCHEMBL12392870 | 0.76 | POLB (0.39) | PRKCAPOLBGAANPSR1CYP4F2 | |
| SCHEMBL16580063 | 0.75 | POLB (0.41) | MEN1LMNAKMT2APRKCAPOLB | |
| SCHEMBL12972547 | 0.75 | NPSR1 (0.41) | LMNAKMT2APRKCAPOLBGAA | |
| SCHEMBL12209931 | 0.74 | DGAT1 (0.34) | LMNAPOLBGAANPSR1 | |
| SCHEMBL13089654 | 0.74 | NPSR1 (0.40) | MEN1LMNAKMT2APRKCAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655378-B2 | Negative resist composition and patterning process using the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2010-02-02 | — | — | US | disclosed |
| US-20080020290-A1 | Negative resist composition and patterning process using the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2008-01-24 | — | — | US | disclosed |