Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985134 | 0.86 | ALDH1A1 (0.32) | MAPTCA1CA2CYP1B1ALDH1A1 | |
| SCHEMBL31070132 | 0.78 | CYP1A2 (0.40) | SMN1; SMN2 | |
| SCHEMBL3083945 | 0.74 | CYP2A6 (0.42) | CYP2A6MAPTLMNAMEN1KMT2A | |
| SCHEMBL2836022 | 0.74 | MAPT (0.44) | CYP2A6MAPTLMNAMEN1KMT2A | |
| SCHEMBL17107320 | 0.74 | ALDH1A1 (0.38) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL515528 | 0.74 | MEN1 (0.43) | CYP2A6MAPTLMNAMEN1KMT2A | |
| SCHEMBL15546400 | 0.74 | CA1 (0.38) | IDO1CA1CA2CNR1 | |
| SCHEMBL9463504 | 0.74 | CA2 (0.46) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL2197474 | 0.74 | MAPT (0.42) | MAPTLMNAMEN1KMT2ANPC1 | |
| Water SCHEMBL11606806 | 0.72 | ALDH1A1 (0.45) | MAPTLMNAMEN1KMT2AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575114-B2 | SGLT-2 inhibitors, methods of making them, and uses thereof | ALBANY MOLECULAR RESEARCH, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-7652062-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH LLC (US) | 2010-01-26 | — | — | US | disclosed |
| CN-101287461-A | Use of 5-amido-1h-pyrrole-2-nitrile derivative as progesterone receptor modulators | WYETH CORP (US) | 2008-10-15 | — | — | CN | disclosed |
| CN-101233103-A | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH CORP (US) | 2008-07-30 | — | — | CN | disclosed |
| EP-1909785-A2 | USE OF PROGESTERONE RECEPTOR MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910284-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | Wyeth (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2008-03-13 | — | — | US | disclosed |
| US-7297713-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| WO-2007016211-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016385-A2 | USE OF SUBSTITUTED 5-AMINO-1H-PYRROLE-2-CARBONITRILE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027201-A1 | Use of progesterone receptor modulators | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-4255565-A | REACTION OF 5-AMINO-1-B-D-RIBOFURANOSYL-4-CYANOIMIDAZOLE AND AN N-CARBO-SUBSTITUTED CYANAMIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | PGR, GNRHR, PGRMC1 | CYP2A6 271/4885MAPT 4465/4885LMNA 4115/4885 |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | PGR, PGRMC1, PGRMC2 | CYP2A6 252/4885MAPT 4574/4885LMNA 4065/4885 |
| US-20070027201-A1 | Use of progesterone receptor modulators | GNRHR, PGR, FSHR | CYP2A6 977/4885MAPT 2474/4885LMNA 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.