Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964234 | 0.92 | EPHX1 (0.46) | EPHX1CES2CES1KMT2AALDH1A1 | |
| SCHEMBL5728127 | 0.92 | EPHX1 (0.46) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Acetone SCHEMBL9529315 | 0.85 | EPHX1 (0.50) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Bicarbonate SCHEMBL4695324 | 0.85 | EPHX1 (0.50) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Bicarbonate SCHEMBL8913592 | 0.85 | EPHX1 (0.50) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Bicarbonate SCHEMBL17847302 | 0.85 | EPHX1 (0.50) | EPHX1CES2CES1KMT2AALDH1A1 | |
| SCHEMBL15764742 | 0.85 | CES2 (0.46) | EPHX1CES2CES1KMT2AALDH1A1 | |
| SCHEMBL8618026 | 0.85 | EPHX1 (0.42) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Acetic Acid SCHEMBL4093239 | 0.82 | EPHX1 (0.48) | EPHX1CES2CES1KMT2AALDH1A1 | |
| Acetic Acid SCHEMBL938460 | 0.82 | EPHX1 (0.48) | EPHX1CES2CES1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250199-B | Dihydropyridone P1 as factor XIA inhibitor | 百时美施贵宝公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-104592231-A | Novel Tricyclic Compounds | ABBVIE INC | 2015-05-06 | — | — | CN | disclosed |
| US-20140235703-A1 | THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235705-A1 | FORMULATIONS OF THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235704-A1 | THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140206888-A1 | METHODS FOR PREPARATION OF THIOPHENE COMPOUNDS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-24 | — | — | US | disclosed |
| EP-2736893-A1 | THIOPHENE COMPOUNDS | Vertex Pharmaceuticals Incorporated (US) | 2014-06-04 | — | — | EP | disclosed |
| US-20130190289-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-25 | — | — | US | disclosed |
| CN-101218224-B | Compositions and methods for treating or preventing flavivirus infections | VIROCHEM PHARMA INC | 2013-05-08 | — | — | CN | disclosed |
| EP-2585447-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-01 | — | — | EP | disclosed |
| CN-1121401-C | aminophenol derivatives | BAYER AG (DE) | 2003-09-17 | — | — | CN | disclosed |
| CN-1349520-A | Novel oxadiazole derivatives as 5-hydroxytryptamine drugs | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| EP-0837860-B1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO(3,4-c]-1,2,4-TRIAZOLO(4,3-ALPHA]PYRIDINES | PFIZER (US) | 2002-03-20 | — | — | EP | disclosed |
| CN-1061044-C | Tricyclic 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4,-triaolo (4,3-alpha] pyridines | PFIZER (US) | 2001-01-24 | — | — | CN | disclosed |
| CN-1240439-A | Aminophenol derivates with fungicidal property | BAYER AG (DE) | 2000-01-05 | — | — | CN | disclosed |
| US-6004974-A | PHOSPHODIESTERASE AND TUMOR NECROSIS FACTOR INHIBITORS; ANTIINFLAMMATORY AND ANTIASTHMA AGENTS | PFIZER INC (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0837860-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO 3,4-c]-1,2,4-TRIAZOLO 4,3-$g(a)]PYRIDINES | PFIZER INC. (US) | 1998-04-29 | — | — | EP | disclosed |
| CN-1142499-A | Tricyclic 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4,-triaolo (4,3-alpha] pyridines | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| WO-1996039408-A1 | TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2,4-TRIAZOLO[4,3-α]PYRIDINES | PFIZER INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| US-4008217-A | HERBICIDE | THE UPJOHN COMPANY (US) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206888-A1 | METHODS FOR PREPARATION OF THIOPHENE COMPOUNDS | CTRC, MC3R, DCLK3 | EPHX1 4326/4885CES2 2827/4885CES1 3894/4885 |
| US-20140235705-A1 | FORMULATIONS OF THIOPHENE COMPOUNDS | TPMT, NAT1, TST | EPHX1 2311/4885CES2 367/4885CES1 328/4885 |
| US-20140235703-A1 | THIOPHENE COMPOUNDS | MAP3K1, MAPK1, PEAK1 | EPHX1 574/4885CES2 4284/4885CES1 1620/4885 |
| US-20130190289-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | SLC10A1, ACE, CEL | EPHX1 2028/4885CES2 315/4885CES1 170/4885 |
| US-20140235704-A1 | THIOPHENE COMPOUNDS | NAMPT, NAPRT, SLC29A1 | EPHX1 4337/4885CES2 1462/4885CES1 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.