Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | SORT1 | Q99523 | 9/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26740884 | 0.92 | KDM4E (0.57) | KDM4EGLAPTGDR2MYCNR4A1 | |
| SCHEMBL30864269 | 0.89 | MAOA (0.53) | KDM4EGLAPTGDR2MYCNR4A1 | |
| SCHEMBL618056 | 0.87 | KDM4E (0.65) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL4441828 | 0.85 | KDM4E (0.63) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL23098988 | 0.79 | KDM4E (0.57) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL29735313 | 0.79 | KDM4E (0.57) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL9450696 | 0.79 | KDM4E (0.62) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL6072149 | 0.79 | ALDH1A1 (0.54) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL22552324 | 0.79 | KDM4E (0.56) | KDM4EGLAMYCNR4A1SORT1 | |
| SCHEMBL1674348 | 0.79 | KDM4E (0.52) | KDM4EGLAPTGDR2MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112375057-A | Preparation method of intermediate IV of roxasistat | 天津敬康生物科技有限公司 | 2021-02-19 | — | — | CN | claimed |
| CN-112375057-A | Preparation method of intermediate IV of roxasistat | 天津敬康生物科技有限公司 | 2021-02-19 | — | — | CN | disclosed |
| US-7674938-B2 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-03-09 | — | — | US | disclosed |
| US-20080249177-A1 | AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF | KISSEI PHARMACEUTICAL CO., LTD. | 2008-10-09 | — | — | US | disclosed |
| CN-100418944-C | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL (JP) | 2008-09-17 | — | — | CN | disclosed |
| US-7423185-B2 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-09-09 | — | — | US | disclosed |
| US-7417169-B2 | Amino alcohol derivatives, medicinal composition containing the same, and use of these | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-08-26 | — | — | US | disclosed |
| EP-1593666-B1 | AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF | KISSEI PHARMACEUTICAL (JP) | 2008-07-02 | — | — | EP | disclosed |
| US-20070078184-A1 | Amino alcohol derivatives, medicinal composition containing the same, and use of these | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-04-05 | — | — | US | disclosed |
| EP-1679304-A1 | AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE | Kissei Pharmaceutical Co., Ltd. (JP) | 2006-07-12 | — | — | EP | disclosed |
| US-20060128807-A1 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-15 | — | — | US | disclosed |
| CN-1751019-A | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL (JP) | 2006-03-22 | — | — | CN | disclosed |
| EP-1593666-A1 | AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2005-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078184-A1 | Amino alcohol derivatives, medicinal composition containing the same, and use of these | ADRB2, ADRA2A, ADRA1A | KDM4E 2845/4885GLA 2163/4885PTGDR2 156/4885 |
| US-20060128807-A1 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | ADRB3, ADRA2C, ADRA1A | KDM4E 2733/4885GLA 2228/4885PTGDR2 571/4885 |
| US-20080249177-A1 | AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF | ADRB3, ADRA2C, ADRA1A | KDM4E 2733/4885GLA 2228/4885PTGDR2 571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.