Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.35 |
| ▸ | ABAT | P80404 | 1/20 | 0.35 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586005 | 0.84 | NFE2L2 (0.54) | NFE2L2KMT2AMEN1APPTRPA1 | |
| SCHEMBL374886 | 0.77 | LMNA (0.60) | CYP2A6ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL22711285 | 0.76 | RELA (0.50) | NFE2L2APPTRPA1 | |
| SCHEMBL1533629 | 0.76 | ALDH1A1 (0.41) | CYP2A6ALDH1A1NFE2L2PPARGKMT2A | |
| SCHEMBL27661663 | 0.76 | RELA (0.50) | NFE2L2APPTRPA1 | |
| SCHEMBL21647821 | 0.76 | RELA (0.50) | NFE2L2APPTRPA1 | |
| SCHEMBL13778825 | 0.74 | APP (0.43) | ALDH1A1NFE2L2KMT2AMEN1LMNA | |
| SCHEMBL19583375 | 0.74 | APP (0.43) | ALDH1A1NFE2L2KMT2AMEN1LMNA | |
| SCHEMBL6405637 | 0.74 | NFE2L2 (0.48) | NFE2L2KMT2AMEN1APPTRPA1 | |
| SCHEMBL1861624 | 0.74 | NFE2L2 (0.48) | NFE2L2KMT2AMEN1APPTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254196-B1 | DENDRIMERS | ISIS INNOVATION (GB) | 2010-11-03 | — | — | EP | disclosed |
| US-7682708-B2 | Dendrimers | ISIS INNOVATION LIMITED (GB) | 2010-03-23 | — | — | US | disclosed |
| US-20080004471-A1 | Dendrimers | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
| US-7276299-B2 | Dendrimers | ISIS INNOVATION LIMITED (GB) | 2007-10-02 | — | — | US | disclosed |
| US-20060252963-A1 | Dendrimers | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2006-11-09 | — | — | US | disclosed |
| US-7083862-B2 | Dendrimers | ISIS INNOVATION LIMITED (GB) | 2006-08-01 | — | — | US | disclosed |
| US-20030134147-A1 | Dendrimers | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 2003-07-17 | — | — | US | disclosed |
| EP-1254196-A1 | DENDRIMERS | ISIS INNOVATION LIMITED (GB) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001059030-A1 | DENDRIMERS | ISIS INNOVATION LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252963-A1 | Dendrimers | NPY1R, CHRM1, TLR1 | CYP2A6 4267/4885ALDH1A1 2905/4885NFE2L2 1315/4885 |
| US-20080004471-A1 | Dendrimers | NPY1R, CHRM1, TLR1 | CYP2A6 4267/4885ALDH1A1 2905/4885NFE2L2 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.