Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | RGS4 | P49798 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213620 | 0.85 | GSK3A (0.50) | RGS4RAD51MEN1KMT2AALDH1A1 | |
| SCHEMBL3203979 | 0.84 | KMT2A (0.45) | APLNRRGS4MEN1KMT2AALDH1A1 | |
| SCHEMBL3201920 | 0.76 | APLNR (0.48) | HTR2AAPLNRRGS4MEN1KMT2A | |
| SCHEMBL5432840 | 0.75 | MAPT (0.54) | APLNRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11000239 | 0.74 | RGS4 (0.44) | RGS4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14519814 | 0.73 | NR3C2 (0.41) | APLNRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13486597 | 0.72 | GSK3A (0.58) | APLNRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL19577090 | 0.71 | APLNR (0.54) | APLNRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL22616743 | 0.70 | APLNR (0.53) | HTR2AAPLNRMEN1KMT2AALDH1A1 | |
| SCHEMBL9387548 | 0.69 | RAB9A (0.60) | APLNRMEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029740-A1 | AZABICYCLIC COMPOUNDS AS SEROTONIN, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | BONANOMI GIORGIO | 2010-02-04 | — | — | US | disclosed |
| US-20100029740-A1 | AZABICYCLIC COMPOUNDS AS SEROTONIN, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | BONANOMI GIORGIO | 2010-02-04 | — | — | US | disclosed |
| EP-2094657-A1 | AZABICYCLIC COMPOUNDS AS SEROTONINE, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | Glaxo Group Limited (GB) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008074716-A1 | AZABICYCLIC COMPOUNDS AS SEROTONINE, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008074716-A1 | AZABICYCLIC COMPOUNDS AS SEROTONINE, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029740-A1 | AZABICYCLIC COMPOUNDS AS SEROTONIN, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS | SLC6A2, SLC6A3, ADRA2C | HTR2A 122/4885SLC6A4 10/4885KCNH2 479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.