Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL2382771 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL220202 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL26048343 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL139789 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL26048324 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL30480961 | 0.93 | KDM4E (0.33) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL2031234 | 0.89 | KDM4E (0.34) | KDM4EMAPTTHRBALOX15NFKB1 | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL7466650 | 0.84 | ALDH1A1 (0.34) | MAPT | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL20919877 | 0.82 | — | — | |
| Snap (S-Nitroso-N-Acetylpenicillamine) SCHEMBL5962171 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0914348-A1 | POLYMERS FOR DELIVERING NITRIC OXIDE IN VIVO | DUKE UNIVERSITY MEDICAL CENTER (US) | 1999-05-12 | — | — | EP | claimed |
| US-5770645-A | THIOLATED NITROSYLATED POLYSACCHARIDE | DUKE UNIVERSITY MEDICAL CENTER (US) | 1998-06-23 | — | — | US | claimed |
| WO-1998005689-A1 | POLYMERS FOR DELIVERING NITRIC OXIDE IN VIVO | DUKE UNIVERSITY MEDICAL CENTER (US) | 1998-02-12 | — | — | WO | claimed |
| US-20250135170-A1 | COMPOSITIONS AND ARTICLES FOR DELIVERING NITRIC OXIDE AND METHODS FOR MAKING AND USING THE SAME | UNIV GEORGIA (US) | 2025-05-01 | — | — | US | disclosed |
| US-20240269353-A1 | NITRIC OXIDE-RELEASING DEVICES | KNOW BIO LLC (US) | 2024-08-15 | — | — | US | disclosed |
| EP-4340612-A1 | NITRIC OXIDE-RELEASING DEVICES | KNOW Bio, LLC (US) | 2024-03-27 | — | — | EP | disclosed |
| WO-2022246319-A1 | NITRIC OXIDE-RELEASING DEVICES | KNOW BIO, LLC (US) | 2022-11-24 | — | — | WO | disclosed |
| US-20140073602-A9 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-20130184237-A1 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| EP-2591009-A1 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | Fresenius Kabi Deutschland GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004004-A1 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
| US-6403759-B2 | SULFIDING/NITROSYLATING CYCLODEXTRINS TO FORM COATING FOR MEDICAL DEVICES (TUBES, CATHETERS) | DUKE UNIVERSITY | 2002-06-11 | — | — | US | disclosed |
| US-20020062020-A1 | High yield S-nitrosylation process | HERRMANN ROBERT A (US) | 2002-05-23 | — | — | US | disclosed |
| US-6359167-B2 | A COMPOUND HAVING A SULFUR-NITRIC OXIDE GROUP (S-N=O) GROUP AS WELL AS A FREE ALCOHOL OR THIOL WITH A HALF-LIFE OF OVER TWELVE HOURS, E.G. S-NITROSO-N-ACETYLPENICILLAMINE; CATHETER COATINGS; SURFACE STERILIZATION | DUKE UNIVERSITY | 2002-03-19 | — | — | US | disclosed |
| WO-2002016320-A2 | HIGH YIELD S-NITROSYLATION PROCESS | SCIMED LIFE SYSTEMS, INC. (US) | 2002-02-28 | — | — | WO | disclosed |
| US-20010020083-A1 | Novel Polymers for Delivering nitric oxide in vivo | STAMLER JONATHAN S (US) | 2001-09-06 | — | — | US | disclosed |
| US-6232434-B1 | MODIFIED POLYSACCHARIDES, CYCLODEXTRINS | DUKE UNIVERSITY MEDICAL CENTER | 2001-05-15 | — | — | US | disclosed |
| US-6207855-B1 | WHICH COMPRISE A STABILIZED S-NITROSYL GROUP AND A FREE ALCOHOL OR A FREE THIOL GROUP. REACTING A POLYTHIOL OR A THIOALCOHOL WITH A NITROSYLATING AGENT, MEDICAL DEVICES COATED WITH THE DISCLOSED COMPOUNDS, NITRIC OXIDE | DUKE UNIVERSITY MEDICAL CENTER | 2001-03-27 | — | — | US | disclosed |
| US-20010000039-A1 | Stable NO-delivering compounds | TOONE ERIC J (US) | 2001-03-15 | — | — | US | disclosed |
| US-5770645-A | THIOLATED NITROSYLATED POLYSACCHARIDE | DUKE UNIVERSITY MEDICAL CENTER (US) | 1998-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020062020-A1 | High yield S-nitrosylation process | APOB, TST, NOS2 | KDM4E 3955/4885MAPT 987/4885THRB 1790/4885 |
| US-20130184237-A1 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | NOS2, NOS3, NOS1 | KDM4E 3621/4885MAPT 4441/4885THRB 4712/4885 |
| US-20140073602-A9 | NITRIC OXIDE DELIVERING HYDROXYALKYL STARCH DERIVATIVES | NOS2, NOS3, NOS1 | KDM4E 3621/4885MAPT 4441/4885THRB 4712/4885 |
| US-20250135170-A1 | COMPOSITIONS AND ARTICLES FOR DELIVERING NITRIC OXIDE AND METHODS FOR MAKING AND USING THE SAME | NOS2, NOS1, NOS3 | KDM4E 2861/4885MAPT 3861/4885THRB 3954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.