Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 4/20 | 0.57 |
| ▸ | FNTB | P49356 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.45 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673014 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1HPGDTPSAB1TPSD1 | |
| SCHEMBL8118154 | 0.84 | SMN1; SMN2 (0.65) | FNTAFNTBSMN1; SMN2NPC1HPGD | |
| SCHEMBL92506 | 0.82 | L3MBTL1 (0.63) | SMN1; SMN2HPGDKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3994894 | 0.81 | MAPT (0.63) | FNTAFNTBSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3581351 | 0.81 | FNTA (0.62) | FNTAFNTBHPGDCYP3A4KDM4E | |
| SCHEMBL29958765 | 0.81 | FNTA (0.62) | FNTAFNTBHPGDCYP3A4KDM4E | |
| SCHEMBL8934908 | 0.81 | ME2 (0.57) | SMN1; SMN2NPC1HPGDTPSAB1TPSD1 | |
| SCHEMBL9090627 | 0.81 | L3MBTL1 (0.61) | SMN1; SMN2HPGDKDM4EALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL20337874 | 0.81 | L3MBTL1 (0.61) | SMN1; SMN2HPGDKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3211666 | 0.79 | HSD11B1 (0.55) | FNTAFNTBHPGDCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |
| EP-2284169-B1 | Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of CNS disorders | OTSUKA PHARMA CO LTD (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |