Tolnaftate

Tolnaftate

SCHEMBL3216288

Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1.O=C(O)S

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.86
MAPT P10636 4/20 0.86
TDP1 Q9NUW8 2/20 0.86
NR1I2 O75469 1/20 0.86
CYP1A2 P05177 1/20 0.86
CYP3A4 P08684 1/20 0.86
CYP2C9 P11712 1/20 0.86
MAPK1 P28482 1/20 0.86
CYP2C19 P33261 1/20 0.86
HTR2B P41595 1/20 0.86
CYP51A1 Q16850 1/20 0.86
SMN1; SMN2 Q16637 3/20 0.46
HTT P42858 1/20 0.46
HSD17B1 P14061 3/20 0.45
HSD17B2 P37059 3/20 0.45
KMT2A Q03164 2/20 0.42
ESR1 P03372 1/20 0.42
MEN1 O00255 1/20 0.42
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tolnaftate SCHEMBL8160019 0.93 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL3520 0.93 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL30382951 0.93 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL29484221 0.93 LMNA (1.00) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL28341077 0.91 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL22227756 0.91 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL10897084 0.91 LMNA (0.97) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL893162 0.89 LMNA (0.88) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL29091994 0.88 LMNA (0.86) LMNAMAPTTDP1NR1I2CYP1A2
Tolnaftate SCHEMBL8985002 0.88 LMNA (0.90) LMNAMAPTTDP1NR1I2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2064246-B1 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION MERCK SHARP & DOHME (US) 2013-05-22 EP claimed
EP-2064246-A2 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION SCHERING CORPORATION (US) 2009-06-03 EP claimed
WO-2008153610-A2 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION SCHERING CORPORATION (US) 2008-12-18 WO claimed
US-20140147442-A1 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION MERCK SHARP & DOHME CORP. (US) 2014-05-29 US disclosed
CN-101668775-B Use of il-23 antagonists for treatment of infection MERCK SHARP & DOHME 2014-05-07 CN disclosed
US-8586035-B2 Use of IL-23 antagonists for treatment of infection MERCK SHARP & DOHME CORP. (US) 2013-11-19 US disclosed
US-20130210925-A1 SUBUNGUICIDE, AND METHOD FOR TREATING ONYCHOMYCOSIS JAY E. BIRNBAUM CONCEPTS LLC (US) 2013-08-15 US disclosed
EP-2064246-B1 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION MERCK SHARP & DOHME (US) 2013-05-22 EP disclosed
US-8404751-B2 Subunguicide, and method for treating onychomycosis HALLUX, INC. (US) 2013-03-26 US disclosed
US-20100291084-A1 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION SCHERING CORPORATION 2010-11-18 US disclosed
CN-101668775-A Use of il-23 antagonists for treatment of infection SCHERING CORP 2010-03-10 CN disclosed
US-20100048724-A1 Subunguicide, and Method for Treating Onychomycosis HALLUX, INC. 2010-02-25 US disclosed
EP-2086316-A2 SUBUNGUICIDE, AND METHOD FOR TREATING ONYCHOMYCOSIS Birnbaum, Jay E. (US) 2009-08-12 EP disclosed
EP-2064246-A2 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION SCHERING CORPORATION (US) 2009-06-03 EP disclosed
WO-2008153610-A2 USE OF IL-23 ANTAGONISTS FOR TREATMENT OF INFECTION SCHERING CORPORATION (US) 2008-12-18 WO disclosed
WO-2008036595-A2 SUBUNGUICIDE, AND METHOD FOR TREATING ONYCHOMYCOSIS BIRNBAUM JAY E (US) 2008-03-27 WO disclosed
US-20070014743-A1 Subunguicide, and method for treating onychomycosis HALLUX, INC. 2007-01-18 US disclosed
US-7135194-B2 Subunguicide, and method for treating onychomycosis HALLUX, INC. 2006-11-14 US disclosed
US-20040062733-A1 Subunguicide, and method for treating onychomycosis HALLUX, INC. 2004-04-01 US disclosed