Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 2/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12715050 | 0.86 | ABL1 (0.79) | ABL1ABCB1BCRHDAC4HDAC2 | |
| SCHEMBL11096260 | 0.84 | ABL1 (0.76) | ABL1ABCB1BCRHDAC4HDAC2 | |
| Acrylic Acid SCHEMBL28215854 | 0.83 | PPARG (0.49) | ABL1ABCB1BCRNR1H4HDAC4 | |
| SCHEMBL3633054 | 0.83 | CA12 (0.61) | HDAC8BACE1CA12CA1CA2 | |
| SCHEMBL10304847 | 0.83 | ABL1 (0.53) | ABL1ABCB1BCRNR1H4HDAC4 | |
| SCHEMBL29551674 | 0.83 | CA12 (0.61) | HDAC8BACE1CA12CA1CA2 | |
| SCHEMBL19440078 | 0.83 | CYP11B2 (0.62) | ABL1ABCB1BCRNR1H4BACE1 | |
| SCHEMBL11819228 | 0.82 | ABL1 (0.73) | ABL1ABCB1BCRHDAC4HDAC2 | |
| SCHEMBL13241127 | 0.82 | ABL1 (0.52) | ABL1ABCB1BCRNR1H4HDAC4 | |
| SCHEMBL8720361 | 0.81 | ABL1 (0.47) | ABL1ABCB1BCRNR1H4HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732552-A | Preparation method of 2-bit or 3-bit thiobenzofuran compound | 天津师范大学 | 2016-07-06 | — | — | CN | claimed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | claimed |
| EP-3315486-B1 | METHOD FOR PRODUCING AROMATIC COMPOUND | TOSOH CORP (JP) | 2023-06-07 | — | — | EP | disclosed |
| CN-108017479-B | Method for producing aromatic compound | 东曹株式会社 | 2022-07-29 | — | — | CN | disclosed |
| US-10246393-B2 | Method for producing aromatic compound | TOSOH CORPORATION (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20180118646-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND | TOSOH CORPORATION (JP) | 2018-05-03 | — | — | US | disclosed |
| US-20180118646-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND | TOSOH CORPORATION (JP) | 2018-05-03 | — | — | US | disclosed |
| WO-2017193288-A1 | SYNTHESIS OF PHOSPHINE LIGANDS BEARING TUNABLE LINKAGE: METHODS OF THEIR USE IN CATALYSIS | THE HONG KONG POLYTECHNIC UNIVERSITY SHENZHEN RESEARCH INSTITUTE (CN) | 2017-11-16 | — | — | WO | disclosed |
| EP-2287141-B1 | METHOD FOR PRODUCING UNSATURATED ORGANIC COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2015-10-21 | — | — | EP | disclosed |
| US-20030008768-A1 | Catalyst for aromatic C-O, C-N, and C-C bond formation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-01-09 | — | — | US | disclosed |
| US-20020137974-A1 | Catalysis using phosphine oxide and sulfoxide compounds | DUPONT POLYMERS, INC. | 2002-09-26 | — | — | US | disclosed |
| EP-1235764-A1 | CATALYSIS USING PHOSPHINE OXIDE COMPOUNDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2002011883-A1 | CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION | YALE UNIVERSITY (US) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002000574-A2 | CATALYSIS USING PHOSPHINE OXIDE AND SULFOXIDE COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2002-01-03 | — | — | WO | disclosed |
| US-6291722-B1 | CONTACTING GRIGNARD REAGENT OF FORMULA R.SUP.7--MGX WITH AN ARYL COMPOUND OF THE FORMULA R.SUP.1--X IN THE PRESENCE OF A CATALYTIC AMOUNT OF COORDINATION COMPRISING TRASITION METAL COMPLEXED TO PHOSPHINE OXIDE TO PREPARE BISARYL COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-09-18 | — | — | US | disclosed |
| WO-2001040147-A1 | CATALYSIS USING PHOSPHINE OXIDE COMPOUNDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2001-06-07 | — | — | WO | disclosed |
| CN-1024011-C | Process for producing cephalosporin compound | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-03-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137974-A1 | Catalysis using phosphine oxide and sulfoxide compounds | TST, GSS, ARSA | ABL1 31/4885ABCB1 3672/4885BCR 953/4885 |
| US-20180118646-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND | HAO2, PAH, TYR | ABL1 22/4885ABCB1 879/4885BCR 30/4885 |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | ABL1 2396/4885ABCB1 236/4885BCR 2239/4885 |
| US-10246393-B2 | Method for producing aromatic compound | HAO2, PAH, TYR | ABL1 22/4885ABCB1 879/4885BCR 30/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | ABL1 1004/4885ABCB1 313/4885BCR 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.