Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231445 | 0.81 | MMP13 (0.67) | SMN1; SMN2ALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL3233111 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL3232618 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HPGDRAB9ATSHR | |
| SCHEMBL3224937 | 0.73 | RAB9A (0.56) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL8335113 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL5214229 | 0.71 | HPGD (0.61) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL24455026 | 0.70 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL29561912 | 0.70 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL8349486 | 0.70 | MMP13 (0.57) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL8348532 | 0.70 | MMP13 (0.57) | SMN1; SMN2ALDH1A1HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | disclosed |