Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232618 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2HRH4RAB9AALDH1A1KMO | |
| SCHEMBL3231445 | 0.78 | MMP13 (0.67) | SMN1; SMN2HRH4RAB9AALDH1A1NAPEPLD | |
| SCHEMBL12168416 | 0.74 | KMO (0.71) | SMN1; SMN2RAB9AALDH1A1KMONPC1 | |
| SCHEMBL3220047 | 0.74 | SMN1; SMN2 (0.65) | SMN1; SMN2HRH4RAB9AALDH1A1KMT2A | |
| SCHEMBL13474216 | 0.73 | KMO (0.73) | SMN1; SMN2RAB9AALDH1A1KMONPC1 | |
| SCHEMBL28825917 | 0.73 | KMO (0.55) | SMN1; SMN2RAB9AALDH1A1KMOKMT2A | |
| SCHEMBL13457037 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AALDH1A1KMOKMT2A | |
| SCHEMBL3232729 | 0.71 | HSD11B1 (0.63) | SMN1; SMN2RAB9AALDH1A1KMOKMT2A | |
| SCHEMBL3226746 | 0.71 | RAB9A (0.63) | SMN1; SMN2RAB9AALDH1A1KMT2AGAA | |
| SCHEMBL19548104 | 0.68 | SMN1; SMN2 (0.61) | SMN1; SMN2HRH4RAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010020432-A8 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA LIMITED (BS) | 2010-03-11 | — | — | WO | claimed |
| WO-2010020432-A2 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2010-02-25 | — | — | WO | claimed |