Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.57 |
| ▸ | RORC | P51449 | 7/20 | 0.57 |
| ▸ | THRA | P10827 | 5/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818059 | 0.87 | RORC (0.70) | THRBRORCTHRA | |
| SCHEMBL5330136 | 0.86 | THRB (0.54) | THRBRORCTHRACYP2D6 | |
| SCHEMBL5324895 | 0.84 | THRB (0.54) | THRBRORCTHRA | |
| SCHEMBL16495807 | 0.84 | THRB (0.54) | THRBRORCTHRA | |
| SCHEMBL3229107 | 0.82 | THRB (0.52) | THRBRORCTHRACYP2D6MAPT | |
| SCHEMBL16496560 | 0.81 | THRB (0.54) | THRBRORCTHRACYP2D6MAPT | |
| SCHEMBL16496559 | 0.81 | THRB (0.54) | THRBRORCTHRACYP2D6MAPT | |
| SCHEMBL5353779 | 0.79 | THRB (0.46) | THRBRORCTHRA | |
| SCHEMBL5326859 | 0.79 | THRB (0.46) | THRBRORCTHRA | |
| SCHEMBL11251015 | 0.77 | CYP2D6 (0.59) | ADRA2AADRA1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420851-B2 | Selective TR-β 1 agonist | CADILA HEALTHCARE LIMITED (IN) | 2013-04-16 | — | — | US | disclosed |
| EP-2079678-B1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LTD (IN) | 2012-12-19 | — | — | EP | disclosed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |
| US-20100048550-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2010-02-25 | — | — | US | disclosed |
| EP-2079678-A2 | SELECTIVE TR-BETA 1 AGONIST | Cadila Healthcare Limited (IN) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008062469-A2 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2008-05-29 | — | — | WO | disclosed |
| WO-2007132475-A1 | SELECTIVE TR-BETA 1 AGONIST | CADILA HEALTHCARE LIMITED (IN) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048550-A1 | SELECTIVE TR-BETA 1 AGONIST | THRB, THRA, TSHR | THRB 1/4885RORC 125/4885THRA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.