Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30940600 | 1.00 | ALDH1A1 (0.36) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL9694327 | 0.81 | ABCB11 (0.33) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL2768046 | 0.80 | ALDH1A1 (0.48) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL17650697 | 0.78 | ABCB11 (0.34) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL17650560 | 0.78 | ALDH1A1 (0.37) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL30438482 | 0.77 | CYP3A4 (0.40) | ALDH1A1CYP3A4HPGDTDP1CES2 | |
| SCHEMBL162877 | 0.77 | CYP3A4 (0.40) | ALDH1A1CYP3A4HPGDTDP1CES2 | |
| SCHEMBL22602688 | 0.77 | APLNR (0.40) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 | |
| SCHEMBL10326019 | 0.74 | GABRA1 (0.38) | MIFP2RY6 | |
| SCHEMBL3287519 | 0.74 | ABCB11 (0.34) | ALDH1A1ABCB11NR3C1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160250175-A1 | COMBINED APPLICATION OF ISOTHIOCYANATE COMPOUND AND ANTI-CANCER MEDICINE | JC (WUXI) COMPANY, INC. (CN) | 2016-09-01 | — | — | US | claimed |
| EP-3034076-A1 | COMBINED APPLICATION OF ISOTHIOCYANATE COMPOUND AND ANTI-CANCER MEDICINE | JC (Wuxi) COMPANY, Inc. (CN) | 2016-06-22 | — | — | EP | claimed |
| CN-105267967-A | Combined application of isothiocyanate-type compound and anti-cancer drug acting or affecting DNA | WUXI JC PHARMACAUTICAL TECHNOLOGY INC | 2016-01-27 | — | — | CN | claimed |
| CN-104415332-A | Combined application between isothiocyanate-type compound and kinase inhibitor medicine in treatment of cancer | WUXI JC PHARMACAUTICAL TECHNOLOGY INC | 2015-03-18 | — | — | CN | claimed |
| CN-104117064-A | Combined application of isothiocyanate compound and hormone medicine | WUXI JC PHARMACAUTICAL TECHNOLOGY INC | 2014-10-29 | — | — | CN | claimed |
| EP-3446689-B1 | ISOTHIOCYANATE COMPOUND FOR USE IN THE TREATMENT OF HYPERBILIRUBINEMIA | JC WUXI COMPANY INC (CN) | 2025-01-08 | — | — | EP | disclosed |
| CN-113262218-B | Use of isothiocyanate compounds | 无锡杰西医药股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| US-11298334-B2 | Use of isothiocyanate compounds | JC (WUXI) COMPANY, INC. (CN) | 2022-04-12 | — | — | US | disclosed |
| CN-113262218-A | Application of isothiocyanate compounds | 无锡杰西医药股份有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-113181160-A | Application of isothiocyanate compounds | 无锡杰西医药股份有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-104173272-B | Sustained-release preparation of isothiocyanate compounds | 无锡杰西医药股份有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-109415602-B | 2-cyanoacrylate-based adhesive composition | 东亚合成株式会社 | 2021-05-25 | — | — | CN | disclosed |
| EP-0286089-B1 | QUINOLINECARBOXYLIC ACID DERIVATIVES, A COMPOSITION COMPRISING THE SAME, PROCESS FOR PREPARING THE SAME, AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICAMENTS | KANEBO, LTD. (JP) | 1991-11-13 | — | — | EP | disclosed |
| US-5011831-A | Bactericides | NIPPON SHINYAKU CO. LTD. (JP) | 1991-04-30 | — | — | US | disclosed |
| EP-0393538-A2 | Thiazetoquinoline-3-Carboxylic acid derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |
| US-4853469-A | BACTERICIDES | KANEBO, LTD. (JP) | 1989-08-01 | — | — | US | disclosed |
| CN-1033054-A | Quinoline carboxylic acid derivative | NIPPON SHINYAKU CO LTD (JP) | 1989-05-24 | — | — | CN | disclosed |
| EP-0315827-A1 | Derivatives of quinolinecarboxylic acid | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1989-05-17 | — | — | EP | disclosed |
| US-4808584-A | Quinolinecarboxylic acid derivatives and antibacterial agent containing the same | KANEBO, LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0286089-A1 | Quinolinecarboxylic acid derivatives, a composition comprising the same, process for preparing the same, and the use of the same for the manufacture of medicaments | KANEBO, LTD. (JP) | 1988-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160250175-A1 | COMBINED APPLICATION OF ISOTHIOCYANATE COMPOUND AND ANTI-CANCER MEDICINE | CHUK, KIT, MKI67 | ALDH1A1 2081/4885ABCB11 619/4885NR3C1 480/4885 |
| US-11298334-B2 | Use of isothiocyanate compounds | LIPC, CETP, LCAT | ALDH1A1 951/4885ABCB11 152/4885NR3C1 2715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.