Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15062363 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL24243983 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL3219761 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2777997 | 0.98 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL38654908 | 0.90 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL20067631 | 0.87 | CA3 (0.59) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL21224801 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL16359229 | 0.83 | EPHX1 (0.55) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL12116757 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL24793189 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120316208-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-12-13 | — | — | US | disclosed |
| US-8273778-B2 | Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-09-25 | — | — | US | disclosed |
| US-8207353-B2 | Poly(ethylene glycol) containing chemically disparate endgroups | INTEZYNE TECHNOLOGIES, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-8084589-B2 | Phosphoramidite nucleoside analogs | UNIVERSITY OF MASSACHUSETTS (US) | 2011-12-27 | — | — | US | disclosed |
| US-7893277-B2 | Poly(ethylene glycol) containing chemically disparate endgroups | INTEZYNE TECHNOLOGIES, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20100280252-A1 | POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS | INTEZYNE TECHNOLOGIES (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100160645-A1 | POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS | INTEZYNE TECHNOLOGIES, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100056586-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-03-04 | — | — | US | disclosed |
| US-7560588-B2 | Poly(ethylene glycol) containing chemically disparate endgroups | INTEZYNE TECHNOLOGIES, INC. (US) | 2009-07-14 | — | — | US | disclosed |
| US-20090136940-A1 | PHOSPHORAMIDITE NUCLEOSIDE ANALOGS | UNIVERSITY OF MASSACHUSETTS (US) | 2009-05-28 | — | — | US | disclosed |
| WO-2009029868-A1 | PHOSPHORAMIDITE NUCLEOSIDE ANALOGS | UNIVERSITY OF MASSACHUSETTS (US) | 2009-03-05 | — | — | WO | disclosed |
| US-20080207913-A1 | Poly(ethylene glycol) containing chemically disparate endgroups | INTEZYNE TECHNOLOGIES (US) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280252-A1 | POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS | GNE, EPRS1, ALG1 | SMN1; SMN2 4039/4885ALDH1A1 2008/4885POLB 447/4885 |
| US-20100160645-A1 | POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS | GNE, EPRS1, ALG1 | SMN1; SMN2 4039/4885ALDH1A1 2008/4885POLB 447/4885 |
| US-20100056586-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | UGDH, UGGT1, UMPS | SMN1; SMN2 4455/4885ALDH1A1 408/4885POLB 429/4885 |
| US-20120316208-A1 | INHIBITORS OF UDP-GALACTOPYRANOSE MUTASE THWART MYCOBACTERIAL GROWTH | UGDH, UGGT1, UMPS | SMN1; SMN2 4455/4885ALDH1A1 408/4885POLB 429/4885 |
| US-20090136940-A1 | PHOSPHORAMIDITE NUCLEOSIDE ANALOGS | TYMP, PNP, TYMS | SMN1; SMN2 1001/4885ALDH1A1 3413/4885POLB 97/4885 |
| US-20080207913-A1 | Poly(ethylene glycol) containing chemically disparate endgroups | GNE, EPRS1, ALG1 | SMN1; SMN2 4039/4885ALDH1A1 2008/4885POLB 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.