Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Aconitic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 5/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.86 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.37 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aconitic Acid SCHEMBL2557134 | 1.00 | TSHR (0.86) | TSHRKDM4ETP53EGLN1EGLN3 | |
| Aconitic Acid SCHEMBL323452 | 1.00 | TSHR (0.86) | TSHRKDM4ETP53EGLN1EGLN3 | |
| Aconitic Acid SCHEMBL16935 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL2022211 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL1275978 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL1289876 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL219037 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL22334 | 0.93 | TSHR (1.00) | TSHRKDM4ECPB1GABRR1GABRR2 | |
| Aconitic Acid SCHEMBL30275008 | 0.90 | TSHR (0.95) | TSHRKDM4ECPB1ALOX15HSD17B10 | |
| Aconitic Acid SCHEMBL29245497 | 0.90 | TSHR (0.95) | TSHRKDM4ECPB1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591027-B1 | STRUCTURED ACRYLATE COPOLYMER THICKENERS | LUBRIZOL ADVANCED MAT INC (US) | 2015-09-23 | — | — | EP | claimed |
| US-8673277-B2 | Structured acrylate copolymer thickeners | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2014-03-18 | — | — | US | claimed |
| EP-2591027-A1 | STRUCTURED ACRYLATE COPOLYMER THICKENERS | Lubrizol Advanced Materials, Inc. (US) | 2013-05-15 | — | — | EP | claimed |
| US-20130115185-A1 | Structured Acrylate Copolymer Thickeners | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2013-05-09 | — | — | US | claimed |
| WO-2012006402-A1 | STRUCTURED ACRYLATE COPOLYMER THICKENERS | LUBRIZOL ADVANCED MATERIALS, INC. (US) | 2012-01-12 | — | — | WO | claimed |
| EP-2591027-B1 | STRUCTURED ACRYLATE COPOLYMER THICKENERS | LUBRIZOL ADVANCED MAT INC (US) | 2015-09-23 | — | — | EP | disclosed |
| EP-0591445-B1 | LIQUID DETERGENT WITH STABILIZED ENZYME | GENENCOR INT (US) | 1999-08-18 | — | — | EP | disclosed |
| EP-0591445-A1 | LIQUID DETERGENT WITH STABILIZED ENZYME | GENENCOR INTERNATIONAL, INC. (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000418-A1 | LIQUID DETERGENT WITH STABILIZED ENZYME | GENENCOR INTERNATIONAL, INC. (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0482417-A1 | Emulsion composition comprising a high molecular weight anionic emulsifying agent and a low molecular weight cationic surfactant, and methods relating thereto | THE B.F. GOODRICH COMPANY (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0459373-A2 | Bioadhesive carboxylic polymer composition and method relating thereto | THE B.F. GOODRICH COMPANY (US) | 1991-12-04 | — | — | EP | disclosed |
| US-5039446-A | Bound to enzyme inhibitor | GENENCOR INTERNATIONAL, INC. (US) | 1991-08-13 | — | — | US | disclosed |