Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231659 | 0.78 | BAZ2B (0.60) | BAZ2BHTR6 | |
| SCHEMBL1120485 | 0.77 | KDM4E (0.64) | SIRT1BAZ2BHTR6 | |
| SCHEMBL1120637 | 0.75 | KIF11 (0.61) | SIRT1KIF11 | |
| SCHEMBL2186300 | 0.75 | BAZ2B (0.50) | SIRT1KIF11BAZ2BMCHR1HTR6 | |
| SCHEMBL26836994 | 0.73 | DRD1 (0.56) | KIF11 | |
| SCHEMBL3720921 | 0.72 | MCHR1 (0.51) | SIRT1KIF11BAZ2BMCHR1HTR6 | |
| SCHEMBL1867588 | 0.72 | BAZ2B (0.81) | SIRT1BAZ2BMAPT | |
| SCHEMBL1120636 | 0.72 | KIF11 (0.60) | SIRT1KIF11MAPTTP53 | |
| SCHEMBL11682584 | 0.72 | SIRT1 (0.77) | SIRT1BAZ2BNR1H2NR1H3 | |
| SCHEMBL167328 | 0.71 | L3MBTL1 (0.70) | BAZ2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481676-B2 | Azepino[4,5-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-11-01 | — | — | US | disclosed |
| US-9409910-B2 | Azepino[4,5-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20140213577-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| US-20140088087-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-8569287-B2 | Azepino[4,5-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20100152163-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152163-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | SIRT1 3401/4885KIF11 3281/4885BAZ2B 1409/4885 |
| US-20140213577-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | SIRT1 3401/4885KIF11 3281/4885BAZ2B 1409/4885 |
| US-20140088087-A1 | AZEPINO[4,5-B]INDOLES AND METHODS OF USE | HTR2C, HTR5A, HTR4 | SIRT1 3401/4885KIF11 3281/4885BAZ2B 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.