Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727571 | 0.87 | ALDH1A1 (0.41) | HSD17B10ADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL6728514 | 0.87 | ADRA2A (0.45) | HSD17B10ADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL6727852 | 0.83 | HSD17B10 (0.50) | HSD17B10ALDH1A1P2RX7CYP3A4CYP2D6 | |
| SCHEMBL6728673 | 0.83 | KMT2A (0.40) | HSD17B10ADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL6727985 | 0.82 | ALDH1A1 (0.43) | ADRA2AADRA2BADRA2CALDH1A1P2RX7 | |
| SCHEMBL6728051 | 0.82 | ALDH1A1 (0.40) | HSD17B10ADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL1156800 | 0.81 | DRD2 (0.37) | HSD17B10DRD2DRD4DRD3ADRA2A | |
| SCHEMBL14000958 | 0.81 | ATM (0.41) | HSD17B10DRD2DRD4DRD3P2RX7 | |
| SCHEMBL6727848 | 0.80 | CYP2D6 (0.58) | HSD17B10ALDH1A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6727927 | 0.80 | ADRA2A (0.47) | HSD17B10ADRA2AADRA2BADRA2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370430-B1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-3H-PYRROL-2-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN INC (US) | 2014-06-04 | — | — | EP | disclosed |
| EP-2370430-B1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-3H-PYRROL-2-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN INC (US) | 2014-06-04 | — | — | EP | disclosed |
| US-8183414-B2 | N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors | ALLERGAN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183414-B2 | N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors | ALLERGAN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183414-B2 | N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors | ALLERGAN, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| WO-2010077586-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-3H-PYRROL-2-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077586-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-3H-PYRROL-2-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
| US-20100145061-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145061-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| US-20100145061-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ALLERGAN, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145061-A1 | N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS | ADRA2B, ADRB2, ADRA2C | HSD17B10 1986/4885DRD2 102/4885DRD4 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.