Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11665214 | 0.97 | LMNA (0.62) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL571834 | 0.86 | MEN1 (0.77) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL1019777 | 0.86 | MEN1 (0.77) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL21632620 | 0.85 | MEN1 (0.56) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL6768157 | 0.85 | ALDH1A1 (0.61) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL21632603 | 0.84 | MEN1 (0.62) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL6535708 | 0.84 | MEN1 (0.62) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3705445 | 0.83 | MEN1 (0.71) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3726684 | 0.83 | MEN1 (0.71) | LMNAMEN1KMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL5429905 | 0.82 | MEN1 (0.83) | LMNAMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103484-A | Process for producing high purity aromatics from mixed aromatic feed streams | 维仁特公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118103485-A | Process for reforming a heavy aromatic stream | 维仁特公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-107567488-B | Jet fuel with reduced emissions of aromatics | 国际壳牌研究有限公司 | 2020-02-14 | — | — | CN | disclosed |
| WO-2010028206-A1 | LIQUID FUEL COMPOSITIONS BASED ON CATALYTICALLY DEOXYGENATED AND CONDENSATED OXYGENATED CARBONHYDRATES | SHELL OIL COMPANY (US) | 2010-03-11 | — | — | WO | disclosed |
| EP-0426759-B1 | NOVEL TC-99M COMPLEXES | MALLINCKRODT, INC. (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5071965-A | NOVEL TC-99M COMPLEXES | MALLINCKRODT MEDICAL, INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0404262-A2 | Monoepoxide-polyol adducts, and process for preparing the same | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-12-27 | — | — | EP | disclosed |