Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242963 | 0.83 | MEN1 (0.46) | MEN1KMT2ANOTUM | |
| SCHEMBL3243453 | 0.78 | MEN1 (0.40) | MEN1KMT2ANPSR1DPP4HSD17B10 | |
| SCHEMBL3242982 | 0.71 | MEN1 (0.43) | MEN1KMT2ADPP4HTR2CHTR2B | |
| SCHEMBL3243682 | 0.66 | MAPT (0.36) | KMT2A | |
| SCHEMBL3240586 | 0.66 | ALDH1A1 (0.39) | MEN1KMT2A | |
| SCHEMBL3246780 | 0.62 | CYP3A4 (0.41) | MEN1KMT2AHSD17B10NOTUMSMN1; SMN2 | |
| SCHEMBL3266459 | 0.62 | MEN1 (0.51) | MEN1KMT2ANOTUM | |
| SCHEMBL3246762 | 0.62 | CYP3A4 (0.41) | MEN1KMT2AHSD17B10NOTUMSMN1; SMN2 | |
| SCHEMBL1519108 | 0.62 | GAA (0.47) | MEN1KMT2AHSD17B10NOTUM | |
| SCHEMBL7316200 | 0.62 | NOTUM (0.51) | KMT2AHSD17B10NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |