Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240586 | 0.88 | ALDH1A1 (0.39) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3243453 | 0.88 | MEN1 (0.40) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3246780 | 0.85 | CYP3A4 (0.41) | MAPTKMT2ASLC6A4SLC6A3CYP1A2 | |
| SCHEMBL3246762 | 0.85 | CYP3A4 (0.41) | MAPTKMT2ASLC6A4SLC6A3CYP1A2 | |
| SCHEMBL3249870 | 0.82 | MAPT (0.37) | MAPTKMT2ASLC6A4SLC6A3SLC6A2 | |
| SCHEMBL3243448 | 0.66 | MEN1 (0.40) | KMT2A | |
| SCHEMBL3243831 | 0.66 | KMT2A (0.44) | MAPTKMT2ASLC6A4SLC6A3CYP3A4 | |
| SCHEMBL14249532 | 0.62 | AADAT (0.42) | KMT2ACYP2C19 | |
| SCHEMBL7654723 | 0.62 | SLC6A2 (0.50) | SLC6A4SLC6A3CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7986945 | 0.62 | PDE5A (0.38) | KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |