Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243682 | 0.88 | MAPT (0.36) | KMT2ALMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3240586 | 0.88 | ALDH1A1 (0.39) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL3246780 | 0.85 | CYP3A4 (0.41) | MEN1KMT2ALMNAHSD17B10NOTUM | |
| SCHEMBL3246762 | 0.85 | CYP3A4 (0.41) | MEN1KMT2ALMNAHSD17B10NOTUM | |
| SCHEMBL3243448 | 0.78 | MEN1 (0.40) | MEN1KMT2ADPP4HSD17B10NPSR1 | |
| SCHEMBL3244940 | 0.77 | DRD2 (0.37) | HSD17B10 | |
| SCHEMBL3242982 | 0.72 | MEN1 (0.43) | MEN1KMT2ADPP4HTR2CHTR2B | |
| SCHEMBL7336655 | 0.72 | NOTUM (0.48) | KMT2ALMNAHSD17B10NOTUMMTNR1A | |
| SCHEMBL7343636 | 0.72 | NOTUM (0.48) | KMT2ALMNAHSD17B10NOTUMMTNR1A | |
| SCHEMBL7338202 | 0.72 | NOTUM (0.48) | KMT2ALMNAHSD17B10NOTUMMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |