Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246762 | 1.00 | CYP3A4 (0.41) | CYP3A4CYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL3240586 | 0.85 | ALDH1A1 (0.39) | CYP3A4CYP2D6CYP1A2CYP2C19MEN1 | |
| SCHEMBL3243682 | 0.85 | MAPT (0.36) | CYP3A4CYP2D6CYP1A2CYP2C19KMT2A | |
| SCHEMBL3243831 | 0.80 | KMT2A (0.44) | CYP3A4CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL3244851 | 0.74 | HTR1A (0.40) | MEN1KMT2ADRD2DRD4 | |
| SCHEMBL3244846 | 0.74 | HTR1A (0.40) | MEN1KMT2ADRD2DRD4 | |
| SCHEMBL3242963 | 0.74 | MEN1 (0.46) | MEN1KMT2ANOTUMALDH1A1LMNA | |
| SCHEMBL17442799 | 0.73 | DRD2 (0.55) | NOTUMLMNADRD2DRD4 | |
| SCHEMBL9294530 | 0.70 | SLC6A2 (0.50) | CYP3A4CYP2D6CYP1A2CYP2C19SLC6A2 | |
| SCHEMBL7654723 | 0.70 | SLC6A2 (0.50) | CYP3A4CYP2D6CYP1A2CYP2C19SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |