Sugi Predict

Sugi Predict / Compounds / SCHEMBL3243480

SCHEMBL3243480

SCHEMBL3243480

O=C(O)c1cc(Cl)nc(C(F)(F)F)c1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TPMT P51580 1/20 0.42
▸ GPBAR1 Q8TDU6 2/20 0.42
▸ HIF1A Q16665 2/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ MEN1 O00255 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ POLB P06746 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ TTR P02766 1/20 0.39
▸ PLA2G1B P04054 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ATG4B Q9Y4P1 1/20 0.38
▸ LOXL2 Q9Y4K0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31443000 1.00 TPMT (0.42) TPMTGPBAR1HIF1AALOX15TSHR
Nitrous Acid SCHEMBL28567917 0.93 GPBAR1 (0.39) TPMTGPBAR1HIF1AALOX15TSHR
SCHEMBL12098246 0.86 ALOX15 (0.48) HIF1AALOX15TSHRLOXL2
SCHEMBL18050067 0.84 GPBAR1 (0.41) GPBAR1HIF1ALMNA
SCHEMBL29723389 0.84 GPBAR1 (0.44) GPBAR1HIF1AHPGDMAPT
SCHEMBL23411999 0.84 GPBAR1 (0.44) GPBAR1HIF1AHPGDMAPT
SCHEMBL5527447 0.81 TPMT (0.42) TPMTHIF1AALOX15TSHRLMNA
SCHEMBL29603089 0.80 NOTUM (0.50) GPBAR1HIF1ALMNAPOLBMAPT
SCHEMBL20186698 0.80 NOTUM (0.50) GPBAR1HIF1ALMNAPOLBMAPT
2,6-Dichloroisonicotinic Acid SCHEMBL56204 0.80 TPMT (0.56) TPMTHIF1AALOX15TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12527325-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2026-01-20 — — US disclosed
US-12514858-B2 CD38 inhibitors Astellas Engineered Small Molecules US, Incorporated (US) 2026-01-06 — — US disclosed
EP-4655296-A1 CBL-B INHIBITORS Aurigene Oncology Limited (IN) 2025-12-03 — — EP disclosed
WO-2025131957-A1 DIAZINONE COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS BASF SE (DE) 2025-06-26 — — WO disclosed
EP-3947358-B1 PESTICIDALLY ACTIVE DIAZINE-AMIDE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2025-06-18 — — EP disclosed
US-12281095-B2 Pesticidally active diazine-amide compounds SYNGENTA CROP PROTECTION AG (CH) 2025-04-22 — — US disclosed
CN-115697985-B CD38 inhibitors 米托布里奇公司 2025-01-21 — — CN disclosed
CN-117903077-B Dihydrooxadiazinone compound and application thereof 上海超阳药业有限公司 2024-09-03 — — CN disclosed
WO-2024156938-A1 CBL-B INHIBITORS ORION CORPORATION (FI) 2024-08-02 — — WO disclosed
CN-117903077-A Dihydrooxadiazinon compound and application thereof 上海超阳药业有限公司 2024-04-19 — — CN disclosed
EP-1984322-B1 BENZAMIDE AND HETEROARENE DERIVATIVES HOFFMANN LA ROCHE (CH) 2012-09-26 — — EP disclosed
US-20120232051-A1 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS HOFFMANN-LA ROCHE INC. 2012-09-13 — — US disclosed
US-20120232051-A1 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS HOFFMANN-LA ROCHE INC. 2012-09-13 — — US disclosed
WO-2012117000-A1 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2012-09-07 — — WO disclosed
US-20120149681-A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION 2012-06-14 — — US disclosed
WO-2012068450-A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2012-05-24 — — WO disclosed
US-7745477-B2 Heteroaryl and benzyl amide compounds HOFFMAN-LA ROCHE INC. (US) 2010-06-29 — — US disclosed
EP-1984322-A1 BENZAMIDE AND HETEROARENE DERIVATIVES F. Hoffmann-la Roche AG (CH) 2008-10-29 — — EP disclosed
WO-2007090748-A1 BENZAMIDE AND HETEROARENE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-08-16 — — WO disclosed
US-20070185058-A1 Heteroaryl and benzyl amide compounds HOFFMANN-LA ROCHE INC. 2007-08-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12527325-B2 Pesticidally active diazine-amide compounds DDT, CHRM1, C3AR1 TPMT 4461/4885GPBAR1 2368/4885HIF1A 3842/4885
US-20120232051-A1 3-AMINO-PYRIDINES AS GPBAR1 AGONISTS GPBAR1, ADRA1B, GPR119 TPMT 1496/4885GPBAR1 1/4885HIF1A 700/4885
US-20070185058-A1 Heteroaryl and benzyl amide compounds CYP1B1, CYP4B1, ABCG2 TPMT 1704/4885GPBAR1 399/4885HIF1A 2390/4885
US-20120149681-A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS JAK1, JAK2, JAK3 TPMT 230/4885GPBAR1 4313/4885HIF1A 3208/4885
US-12281095-B2 Pesticidally active diazine-amide compounds DDT, ACHE, NIT2 TPMT 2555/4885GPBAR1 2382/4885HIF1A 4635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.