Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249740 | 0.89 | BRAF (0.40) | BRAFKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL3251387 | 0.87 | POLB (0.40) | BRAFKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL3249820 | 0.87 | BRAF (0.49) | BRAFKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL3248591 | 0.85 | TAS2R14 (0.43) | KDM4EPOLBTDP1L3MBTL1ALOX15 | |
| SCHEMBL3247431 | 0.83 | MAPT (0.48) | KDM4EPOLBALDH1A1USP2HPGD | |
| SCHEMBL3241840 | 0.82 | KDM4E (0.41) | KDM4EPOLBTDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3250608 | 0.82 | BRAF (0.53) | BRAFKDM4EPOLBTDP1L3MBTL1 | |
| SCHEMBL3250557 | 0.81 | MAPT (0.41) | BRAFKDM4EPOLBL3MBTL1CA12 | |
| SCHEMBL3250591 | 0.81 | PARG (0.48) | BRAFKDM4EPOLBTDP1ALDH1A1 | |
| SCHEMBL3249059 | 0.81 | MAPT (0.47) | BRAFKDM4EPOLBTDP1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |