Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246175 | 0.89 | BRAF (0.48) | BRAFPOLBKDM4ETDP1L3MBTL1 | |
| SCHEMBL3251387 | 0.88 | POLB (0.40) | BRAFPOLBKDM4ETDP1L3MBTL1 | |
| SCHEMBL3245998 | 0.86 | KDM4E (0.41) | BRAFPOLBKDM4ETDP1L3MBTL1 | |
| SCHEMBL3248591 | 0.86 | TAS2R14 (0.43) | POLBKDM4ETDP1L3MBTL1TP53 | |
| SCHEMBL3241840 | 0.85 | KDM4E (0.41) | POLBKDM4ETDP1L3MBTL1PARP1 | |
| SCHEMBL3250557 | 0.84 | MAPT (0.41) | BRAFPOLBKDM4EL3MBTL1TP53 | |
| SCHEMBL3250430 | 0.82 | HSD17B10 (0.45) | BRAFPOLBKDM4ETDP1TP53 | |
| SCHEMBL3249059 | 0.82 | MAPT (0.47) | BRAFPOLBKDM4ETDP1TP53 | |
| SCHEMBL3250591 | 0.82 | PARG (0.48) | BRAFPOLBKDM4ETDP1MAPT | |
| SCHEMBL3253968 | 0.82 | PKM (0.49) | BRAFPOLBKDM4ETDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |