Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GGT1 | P19440 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18112552 | 0.79 | MEN1 (0.38) | KDM4EALDH1A1HSD17B10TDP1HPGD | |
| SCHEMBL22982229 | 0.78 | — | — | |
| SCHEMBL64917 | 0.75 | CYP1A2 (0.40) | KDM4EALDH1A1MAPTPOLBMAPK1 | |
| SCHEMBL5227738 | 0.75 | CYP1A2 (0.40) | KDM4EALDH1A1MAPTPOLBMAPK1 | |
| SCHEMBL8533924 | 0.75 | — | — | |
| SCHEMBL3237917 | 0.75 | CA1 (0.30) | — | |
| SCHEMBL3307482 | 0.75 | MTNR1A (0.32) | ALDH1A1BLMTSHRMAPT | |
| SCHEMBL1451151 | 0.74 | HSD17B10 (0.46) | KDM4EALDH1A1HSD17B10PTGS2BLM | |
| SCHEMBL20524986 | 0.74 | CYP2A6 (0.32) | ALDH1A1HSD17B10TDP1TSHR | |
| SCHEMBL6553858 | 0.72 | SMN1; SMN2 (0.42) | KDM4EALDH1A1PTGS2TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099875-A1 | NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS | PHOSPHOENIX SARL (FR) | 2010-04-22 | — | — | US | claimed |
| US-20050191567-A1 | Oxime ester photoinitiators | KUNIMOTO KAZUHIKO (JP) | 2005-09-01 | — | — | US | claimed |
| US-20040116703-A1 | 8-Azabicyclo[3.2.1]oct-2-ene and -octane derivatives technical field | NEUROSEARCH A/S | 2004-06-17 | — | — | US | claimed |
| EP-1133494-B1 | 8-AZABICYCLO 3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES | NEUROSEARCH AS (DK) | 2004-02-18 | — | — | EP | claimed |
| US-6680328-B2 | CHOLINERGIC LIGANDS OF NICOTINIC ACETYL CHOLINE RECEPTORS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, SMOOTH MUSCLE CONTRACTION DISORDERS, ENDOCRINE DISEASES/DISORDERS, NEURODEGENERATION, INFLAMMATION, PAIN, AND DRUG WITHDRAWAL | NEUROSEARCH A/S (DK) | 2004-01-20 | — | — | US | claimed |
| US-20020035122-A1 | 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives | ANIONA APS (DK) | 2002-03-21 | — | — | US | claimed |
| EP-1133494-A1 | 8-AZABICYCLO 3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2001-09-19 | — | — | EP | claimed |
| US-20010012596-A1 | For resist applications; thermostability, storage stability | CIBA SPECIALTY CHEMICALS CORP. | 2001-08-09 | — | — | US | claimed |
| WO-2000032600-A1 | 8-AZABICYCLO[3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2000-06-08 | — | — | WO | claimed |
| CN-115943147-A | N-linked macrocyclic 7- (pyrazol-5-yl) -indole derivatives as MCL-1 inhibitors | 詹森药业有限公司 | 2023-04-07 | — | — | CN | disclosed |
| US-20190315734-A1 | PURIFICATION METHOD FOR 5-(THIAZOL-4-YL)INDOLIN-2-ONE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2019-10-17 | — | — | US | disclosed |
| US-10377749-B2 | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2019-08-13 | — | — | US | disclosed |
| US-8420396-B2 | For delivering DNA/RNA into cells | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| EP-1167366-B1 | AMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-05-05 | — | — | EP | disclosed |
| EP-1167366-A1 | AMINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
| EP-1133494-A1 | 8-AZABICYCLO 3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2001-09-19 | — | — | EP | disclosed |
| US-20010012596-A1 | For resist applications; thermostability, storage stability | CIBA SPECIALTY CHEMICALS CORP. | 2001-08-09 | — | — | US | disclosed |
| WO-2000032600-A1 | 8-AZABICYCLO[3.2.1]OCT-2-ENE AND -OCTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2000-06-08 | — | — | WO | disclosed |
| US-4918046-A | DISULFONATES AND COLORLESS OR LIGHT-COLORED COLORING MATERIAL; DISCOLORATION INHIBITION | ADEKA ARGUS CHEMICAL CO., LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| US-4147806-A | Anti-inflammatory and analgesic medicaments | LABORATOIRES CREAT (FR) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10377749-B2 | Purification method for 5-(thiazol-4-yl)indolin-2-one derivative | HRH4, CHRM2, CHRM1 | KDM4E 3919/4885ALDH1A1 743/4885HSD17B10 898/4885 |
| US-20020035122-A1 | 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives | CHRNA2, CHRNA7, CHRNA10 | KDM4E 631/4885ALDH1A1 1594/4885HSD17B10 1494/4885 |
| US-20100099875-A1 | NEW ORTHO-FUNCTIONALIZED P-CHIRAL ARYLPHOSPHINES AND DERIVATIVES: THEIR PREPARATION AND USE IN ASYMMETRIC CATALYSIS | PNP, NANP, PHOSPHO1 | KDM4E 2286/4885ALDH1A1 834/4885HSD17B10 1267/4885 |
| US-20190315734-A1 | PURIFICATION METHOD FOR 5-(THIAZOL-4-YL)INDOLIN-2-ONE DERIVATIVE | HRH4, CHRM2, CHRM1 | KDM4E 3919/4885ALDH1A1 743/4885HSD17B10 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.