Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248781 | 0.91 | KDM4E (0.40) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL3250416 | 0.86 | CDK4 (0.46) | KDM4EALDH1A1HPGDGAANPSR1 | |
| SCHEMBL3254551 | 0.83 | ALDH1A1 (0.52) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL3249865 | 0.82 | KDM4E (0.40) | GABRA1GABRA5GABRA3GABRA2GABRA6 | |
| SCHEMBL3248921 | 0.82 | ALDH1A1 (0.41) | GABRA1KDM4EALDH1A1HPGDHTT | |
| SCHEMBL3245727 | 0.82 | GABRA1 (0.50) | GABRA1GABRA3ALDH1A1HPGDNPSR1 | |
| SCHEMBL3251609 | 0.82 | PARP1 (0.44) | ALDH1A1HPGDSMN1; SMN2L3MBTL1HSD17B10 | |
| SCHEMBL3254034 | 0.82 | ALOX15 (0.47) | — | |
| SCHEMBL3252529 | 0.82 | ALDH1A1 (0.47) | GABRA1GABRA3KDM4EALDH1A1HPGD | |
| SCHEMBL3255332 | 0.82 | ADORA3 (0.40) | GABRA1GABRA3KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |