Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 5/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251609 | 0.86 | PARP1 (0.44) | CDK4CCND1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3254034 | 0.86 | ALOX15 (0.47) | ALOX15 | |
| SCHEMBL3249865 | 0.86 | KDM4E (0.40) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL3247793 | 0.86 | GABRA1 (0.46) | ALDH1A1HSD17B10KDM4EHPGDHTT | |
| SCHEMBL3254865 | 0.83 | ALDH1A1 (0.47) | CDK4CCND1BCHEACHEALDH1A1 | |
| SCHEMBL3248781 | 0.82 | KDM4E (0.40) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL3245727 | 0.80 | GABRA1 (0.50) | CDK4CCND1ALDH1A1KMT2AMEN1 | |
| SCHEMBL3248921 | 0.80 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1HSD17B10KDM4E | |
| SCHEMBL3252529 | 0.80 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1HSD17B10ALOX15 | |
| SCHEMBL3255332 | 0.80 | ADORA3 (0.40) | ALDH1A1KMT2AMEN1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |