Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CTSG | P08311 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251110 | 0.90 | ALDH1A1 (0.37) | TRPV1TAAR1LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL3255401 | 0.88 | P2RX7 (0.39) | P2RX7TRPV1KMT2AMEN1CTSL | |
| SCHEMBL3258306 | 0.87 | P2RX7 (0.39) | P2RX7TRPV1KCNH2GAAALDH1A1 | |
| SCHEMBL3257098 | 0.86 | TAAR1 (0.39) | KMT2ATAAR1 | |
| SCHEMBL3258744 | 0.84 | P2RX7 (0.38) | P2RX7KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL3256647 | 0.83 | P2RX7 (0.34) | P2RX7CTSLELANECTSGCTSS | |
| SCHEMBL3255405 | 0.82 | ALDH1A1 (0.41) | KMT2AMEN1GAAALDH1A1ALOX5 | |
| SCHEMBL3256725 | 0.81 | GAA (0.33) | P2RX7LMNAGAASMN1; SMN2 | |
| SCHEMBL3253833 | 0.81 | CES1 (0.41) | P2RX7LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL3259233 | 0.81 | P2RX7 (0.41) | P2RX7TAAR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |