Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253134 | 0.90 | HSD11B1 (0.39) | KMT2AMEN1IDEP2RX7ALDH1A1 | |
| SCHEMBL3257493 | 0.88 | ALDH1A1 (0.38) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3255000 | 0.87 | P2RX7 (0.43) | P2RX7ALDH1A1LMNA | |
| SCHEMBL3259173 | 0.87 | ALDH1A1 (0.39) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3256724 | 0.83 | P2RX7 (0.39) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3258335 | 0.82 | ALDH1A1 (0.38) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3255413 | 0.82 | ALDH1A1 (0.38) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3251176 | 0.82 | ALDH1A1 (0.35) | P2RX7ALDH1A1CYP2C19LMNA | |
| SCHEMBL3258394 | 0.81 | P2RX7 (0.42) | KMT2AMEN1P2RX7ALDH1A1 | |
| SCHEMBL3256757 | 0.80 | RPA1 (0.34) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |