Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255825 | 0.90 | PDPK1 (0.36) | GAATP53THRBMEN1KMT2A | |
| SCHEMBL3254057 | 0.89 | TP53 (0.42) | GAARAB9ATP53MEN1KMT2A | |
| SCHEMBL3258687 | 0.88 | GPBAR1 (0.39) | GAAGPBAR1KMT2ASMN1; SMN2 | |
| SCHEMBL3253146 | 0.88 | SMN1; SMN2 (0.37) | GAARAB9AADAM17GPBAR1TP53 | |
| SCHEMBL3256757 | 0.88 | RPA1 (0.34) | GAARAB9A | |
| SCHEMBL3253367 | 0.86 | KDM1A (0.35) | GAARAB9ATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL3255382 | 0.84 | CYP1A2 (0.37) | GAARAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3258561 | 0.82 | PDPK1 (0.39) | MEN1KMT2A | |
| SCHEMBL3255000 | 0.81 | P2RX7 (0.43) | TP53ALDH1A1 | |
| SCHEMBL3253979 | 0.81 | CHRM5 (0.36) | GAARAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |