Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4838658 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL106605 | 0.95 | — | — | |
| Maleic Acid SCHEMBL5556979 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL52800 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL4816794 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL122080 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7568616 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL4838648 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL52799 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL28080180 | 0.95 | TSHR (0.90) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687571-B2 | Swellable elastomer-based apparatus, oilfield elements comprising same, and methods of using same in oilfield applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2010-03-30 | — | — | US | disclosed |
| US-7631697-B2 | Oilfield apparatus comprising swellable elastomers having nanosensors therein and methods of using same in oilfield application | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2009-12-15 | — | — | US | disclosed |
| CN-101545371-A | Oil field device of swellable elastic body provided with nano sensors inside and method using same in oil field application | PRADER RES AND DEV CO LTD | 2009-09-30 | — | — | CN | disclosed |
| US-20080194717-A1 | SWELLABLE ELASTOMER-BASED APPARATUS, OILFIELD ELEMENTS COMPRISING SAME, AND METHODS OF USING SAME IN OILFIELD APPLICATIONS | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-08-14 | — | — | US | disclosed |
| US-20080125335-A1 | Oilfield Apparatus Comprising Swellable Elastomers Having Nanosensors Therein And Methods Of Using Same In Oilfield Application | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-05-29 | — | — | US | disclosed |
| US-7373991-B2 | Swellable elastomer-based apparatus, oilfield elements comprising same, and methods of using same in oilfield applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2008-05-20 | — | — | US | disclosed |
| US-20070027245-A1 | Swellable Elastomer-Based Apparatus, Oilfield Elements Comprising Same, and Methods of Using Same in Oilfield Applications | SCHLUMBERGER TECHNOLOGY CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |