Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731066 | 0.81 | SIGMAR1 (0.43) | SIGMAR1CHRNA7POLBKMT2AL3MBTL1 | |
| SCHEMBL7501330 | 0.77 | LTA4H (0.45) | SIGMAR1CHRNA7KMT2ALTA4HPTGS2 | |
| SCHEMBL2215851 | 0.74 | HRH3 (0.41) | SIGMAR1POLBKMT2ALTA4HPTGS2 | |
| SCHEMBL7502501 | 0.73 | LTA4H (0.50) | SIGMAR1KMT2ALTA4HLMNAHRH3 | |
| SCHEMBL7500095 | 0.71 | HPGD (0.50) | CHRNA7KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL11083943 | 0.70 | KMT2A (0.46) | CHRNA7POLBKMT2ALIPELMNA | |
| SCHEMBL1002275 | 0.70 | HTR7 (0.42) | SIGMAR1POLBKMT2ALTA4HPTGS2 | |
| SCHEMBL1002277 | 0.70 | HTR7 (0.42) | SIGMAR1POLBKMT2ALTA4HPTGS2 | |
| SCHEMBL992649 | 0.70 | HRH3 (0.40) | SIGMAR1HRH3 | |
| SCHEMBL997427 | 0.69 | TP53 (0.39) | SIGMAR1POLBKMT2ALTA4HPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008666-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |